13241-36-6

Basic information

• Product Name: 1,4:3,6-dianhydro-D-threo-hexo-2,5-diulose
• Synonyms: 1,4:3,6-dianhydro-D-threo-hexo-2,5-diulose;1,4:3,6-Dianhydro-D-threo-2,5-hexodiulose;FCUGRBLTSOXBKO-UHFFFAOYSA-N;(3aS,6aS)-3a,6a-dihydrofuro[5,4-d]furan-3,6-dione
• CAS NO: 13241-36-6
• Molecular Formula: C₆H₆O₄
• Molecular Weight: 142.1094
• EINECS: 236-217-4
• Mol File: 13241-36-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 317.9°Cat760mmHg
• Flash Point: 146.1°C
• Appearance: /
• Density: 1.741g/cm³
• Vapor Pressure: 3.1E-05mmHg at 25°C
• Refractive Index: 1.693
• CAS DataBase Reference: 1,4:3,6-dianhydro-D-threo-hexo-2,5-diulose(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4:3,6-dianhydro-D-threo-hexo-2,5-diulose(13241-36-6)
• EPA Substance Registry System: 1,4:3,6-dianhydro-D-threo-hexo-2,5-diulose(13241-36-6)

Safety Data

• Hazardous Substances Data: 13241-36-6(Hazardous Substances Data)

Usage

General Description

1,4:3,6-Dianhydro-D-threo-hexo-2,5-diulose, commonly known as isosorbide, is a chemical compound with a variety of industrial and pharmaceutical applications. It is a heterocyclic compound derived from glucose and is used as a building block for polymers, particularly in the production of biodegradable plastics. Isosorbide is also a potential alternative to traditional petrochemical-based plastics, offering a more sustainable and environmentally friendly option. In the pharmaceutical industry, isosorbide is used in the production of certain medications, including vasodilators and diuretics. It is also being researched for its potential therapeutic effects in the treatment of various medical conditions, such as cardiovascular disease and cancer.

InChI:InChI=1/C6H6O4/c7-3-1-9-6-4(8)2-10-5(3)6/h1-2,5-8H

Upstream product

• 652-67-5 Isosorbide 
• 641-74-7 1,4:3,6-dianhydro-D-mannitol 

Downstream Products

• 48107-55-7 (3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diamine 
• 48107-55-7 2,5-diamino-1,4:3,6-dianhydro-2,5-dideoxy-L-iditol,DAI 
• 106182-72-3 (3R,3aR,6R,6aR)-6-aminohexahydrofuro[3,2-b]furan-3-ylamine 

Relevant articles and documents

Method for Direct Synthesis of Isosorbide Diketone from Isosorbide Using (2,2,6,6-Tetramethylpiperidin-1-yl)oxyl-based Derivatives and Transition Metal Nitrates

According to an embodiment of the present disclosure, provided are: a (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO)-based derivative; and a method for direct synthesizing isosorbide diketone from isosorbide under mild reaction conditions without using highly toxic and corrosive acid components by improving reaction mechanism by a catalyst system comprising nitrates of a transition metal.COPYRIGHT KIPO 2020

Aerobic oxidation of isosorbide and isomannide employing TEMPO/laccase

The oxidation of the renewable diols isosorbide and isomannide was successfully achieved using a TEMPO/laccase system. Furthermore, various TEMPO-derivatives were tested leading to conversions of up to >99% for the oxidation of isosorbide, isomannide, indanol and a halohydrin to the corresponding ketone. the Partner Organisations 2014.

METHOD FOR PRODUCING ALDEHYDES AND KETONES FROM PRIMARY AND SECONDARY ALCOHOLS

The invention relates to a method for producing aldehydes and ketones from easily accessible primary and secondary alcohols by oxidation with atmospheric oxygen or pure oxygen using a catalyst system which consists of a derivative of a free nitroxyl radical.