132418-36-1

Basic information

• Product Name: Rocepafant
• Synonyms: Rocepafant;4H-Pyrido(4',3':4,5)thieno(3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine-9(8H)-carbothioamide, 7,10-dihydro-6-(2-chlorophenyl)-N-(4-methoxyphenyl)-1-methyl-;6-(o-Chlorophenyl)-7,10-dihydro-1-methylthio-4H-pyrido(4',3':4,5)thieno(3,2-F)-S-triazolo(4,3-A)(1,4)diazepine-9(8H)-carboxy-p-anisidide;Unii-4kgx1sty2n
• CAS NO: 132418-36-1
• Molecular Formula: C₂₆H₂₃ClN₆OS₂
• Molecular Weight: 535.094
• Mol File: 132418-36-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 754.4°Cat760mmHg
• Flash Point: 410°C
• Appearance: /
• Density: 1.49g/cm³
• Vapor Pressure: 1.21E-22mmHg at 25°C
• Refractive Index: 1.766
• CAS DataBase Reference: Rocepafant(CAS DataBase Reference)
• NIST Chemistry Reference: Rocepafant(132418-36-1)
• EPA Substance Registry System: Rocepafant(132418-36-1)

Safety Data

• Hazardous Substances Data: 132418-36-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C26H23ClN6OS2/c1-15-30-31-22-13-28-24(18-5-3-4-6-20(18)27)23-19-11-12-32(14-21(19)36-25(23)33(15)22)26(35)29-16-7-9-17(34-2)10-8-16/h3-10H,11-14H2,1-2H3,(H,29,35)

Upstream product

• 114800-58-7 6-(2-chlorophenyl)-11-methyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 

Relevant articles and documents

Synthesis and use of thienotriazolodiazepines

A new method to synthesize the platelet-activating factor antagonist which is a derivative of thienotriazolodiazepene, tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methosy-4 phenyl carbamoyl)-9 pyrido[4,3-:4,5] thieno[3,2-f] triazolo-1,2,4 [4,3-α] diazepine-1,4] (1) is disclosed. The compound synethesized by this new method has been designated “LAU-8080” which has the same structure as the compound currently named in the literature as “BN-50730.” LAU-8080 was shown to prevent photoreceptor cell death, inhibit pathological neovascularization in the retina, and minimize the loss of neurons due to ischemic-reperfusion damage due to stroke. Thus LAU-8080 can be used to treat the retinal diseases of age-related macular degeneration, retinitis pigmentosa, and diabetic retinopathy. It can also be used to minimize the neuronal damage due to stroke. 1