13242-51-8

Basic information

• Product Name: 4-Nitrophenyl 2,3,4,6-Tri-O-acetyl-α-D-mannopyranoside
• Synonyms: 4-Nitrophenyl 2,3,4,6-Tri-O-acetyl-α-D-mannopyranoside;4-Nitrophenyl α-D-Mannopyranoside 2,3,4,6-Tetraacetate;p-Nitrophenyl 2,3,4,6-Tetra-O-acetyl-α-D-Mannopyranoside
• CAS NO: 13242-51-8
• Molecular Formula: C₂₀H₂₃NO₁₂
• Molecular Weight: 469.39612
• Product Categories: 13C & 2H Sugars;Carbohydrates & Derivatives
• Mol File: 13242-51-8.mol
• Article Data: 44

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Nitrophenyl 2,3,4,6-Tri-O-acetyl-α-D-mannopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitrophenyl 2,3,4,6-Tri-O-acetyl-α-D-mannopyranoside(13242-51-8)
• EPA Substance Registry System: 4-Nitrophenyl 2,3,4,6-Tri-O-acetyl-α-D-mannopyranoside(13242-51-8)

Safety Data

• Hazardous Substances Data: 13242-51-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

4-Nitrophenyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside (cas# 13242-51-8) is a compound useful in organic synthesis.

Upstream product

• 100-02-7 4-nitro-phenol 
• 83-87-4 D-Mannose pentaacetate 
• 13242-53-0 acetobromomannose 
• 3068-32-4 1-bromo-1-deoxy-2,3,4,6-tetra-O-acetyl-a-D-galactopyranoside 
• 108-24-7 acetic anhydride 
• 3150-24-1 4-nitrophenyl-β-D-galactopyranoside 
• 3947-62-4 2,3,4,6-tetra-O-acetyl-α/β-D-galactopyranose 
• 1420786-80-6 C₂₉H₂₈O₁₁ 
• 24067-17-2 4-nitrophenylboronic acid 
• 10257-28-0 D-Galactose 
• 3068-32-4 1-bromo-2,3,4,6-tetra-O-acetyl-D-galactopyranose 
• 572-09-8 acetobromogalactose 
• 86520-63-0 2,3,4,6-tetra-O-acetyl-α-galactopyranosyl trichloroacetimidate 
• 7512-17-6 N-Acetyl-D-glucosamine 

Downstream Products

• 187146-99-2 p-Aminophenyl-2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 
• 42011-36-9 (2R,3S,4S,5R,6S)-2-(acetoxymethyl)-6-(4-aminophenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1427462-40-5 5-(-N-(p-O-(2,3,4,6-tetra-O-acetyl-β-D-galactosyl)phenyl)-aminocarbonyl)-2,2'-bipyridine 
• 1427462-44-9 5-(-N-(p-O-(β-D-galactosyl)phenyl)-aminocarbonyl)-2,2'-bipyridine 
• 5094-33-7 p-aminophenyl β-D-galactopyranoside 

Relevant articles and documents

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Nitrogen-containing aromatic ring derivative containing galactose and application thereof

The invention belongs to the technical field of medicines, and relates to a nitrogen-containing aromatic ring derivative containing galactose, application thereof and a pharmaceutical composition containing the compound. The invention also relates to a method for preparing the compound and the pharmaceutical composition, and application of the compound and the pharmaceutical composition in prevention or treatment of tumors, inflammatory diseases, autoimmune diseases and other diseases, especially tumors.

Brain-targeting nano liposome carrying positively charged polymer/miR-195 compound, and preparation method and application thereof

The invention relates to a brain-targeting nano liposome carrying a positively charged polymer/miR-195 compound, and a preparation method and application thereof, and belongs to the technical field oftargeting drug delivery. In order to improve stability of nucleic acid therapeutic drugs and penetration of blood brain barriers, the invention provides the brain targeting nano liposome carrying thepositively charged polymer/miR-195 compound, wherein the liposome containing a glycosyl modified polyethylene glycol phospholipid and a cell penetrating peptide modified polyethylene glycol phospholipid is taken as a drug carrier to envelop the positively charged polymer/miR-195 compound. According to the invention, stability of miR-195 is improved through the positively charged polymer and the drug carrier, and capability of the drug to target the brain and penetrate the cell membrane is improved through the glycosyl combined cell penetrating peptide modified brain targeting nano liposome, so that the carried drugs efficiently and specifically target brain tissues to treat Alzheimer's disease and vascular dementia, particularly cognitive dysfunction caused by Alzheimer's disease and cerebral ischemia.

Chemo-enzymatic synthesis of p-nitrophenyl β-D-galactofuranosyl disaccharides from Aspergillus sp. fungal-type galactomannan

β-D-Galactofuranose (Galf) is a component of polysaccharides and glycoconjugates. There are few reports about the involvement of galactofuranosyltransferases and galactofuranosidases (Galf-ases) in the synthesis and degradation of galactofuranose-containing glycans. The cell walls of filamentous fungi in the genus Aspergillus include galactofuranose-containing polysaccharides and glycoconjugates, such as O-glycans, N-glycans, and fungal-type galactomannan, which are important for cell wall integrity. In this study, we investigated the synthesis of p-nitrophenyl β-D-galactofuranoside and its disaccharides by chemo-enzymatic methods including use of galactosidase. The key step was selective removal of the concomitant pyranoside by enzymatic hydrolysis to purify p-nitrophenyl β-D-galactofuranoside, a promising substrate for β-D-galactofuranosidase from Streptomyces species.