132425-06-0Relevant academic research and scientific papers
Traceurs biomedicaux - Etude physycochimique du Fe3BTMP
Vincens, M.,Mollier, H.,Naini, A.,Toulhoat, C.,Vidal, M.,et al.
, p. 822 - 831 (2007/10/02)
Biomedical tracers - Study of the properties of Fe3BTMP.The complex benzene-1,2,4,5-tetra(methylenephosphonato)triferrate III 4, Fe3BTMP, is a contrast agent for liver MRI (magnetic resonance imaging).The stoichiometries 1:1 and 3:1 were found for FeBTMP 3 and Fe3BTMP 4 using polarography and 31P NMR.At physiological pH and in aqueous solution these complexes are more stable than FeTTMP (5') and as stable as FeN3TMP (6').It was found that 3 and 4 are polymers with linear and polydimensional structures respectively. - - - benzene tetraphosphonic cyclopendents / iron (III) complexes / stability / MRI contrast agents
Organophosphorus osteotropic cyclopodands.
Mollier, H.,Vincens, M.,Vidal, M.,Pasqualini, R.,Duet, M.
, p. 787 - 795 (2007/10/02)
Various phosphorus containing ligands (including phosphonic acids, phosphinic acids and phosphine oxide derivatives) have been synthesized and complexed to technetium.The species derived from benzene-1,2,4,5-tetra(methylenephosphonic) acid (BTMP) and 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetra-(methylenephosphonic) acid (TTMP) which are osteotropic vectors have demonstrated excellent tracing properties on animal tests.These tracers however were less effective upon human tests.The differences in their respective biological activities led us to investigate their physicochemical properties in solution. Key Words: organophosphorus cyclopodands / phosphonic acid / technetium / complexes / osteotropic tracers
