132426-19-8

Basic information

• Product Name: 2-Bromo-1-pyrazin-2-ylethanone
• Synonyms: Ethanone, 2-bromo-1-pyrazinyl-;Ethanone, 2-bromo-1-pyrazinyl- (9CI);2-BROMO-1-PYRAZINYL ETHANONE;2-Bromo-1-pyrazin-2-ylethanone;2-BroMo-1-(2-pyrazinyl) Ethanone;2-(2-BroMoacetyl)pyrazine;2-(BroMoacetyl)pyrazine;2-Bromo-1-(pyrazin-2-yl)
• CAS NO: 132426-19-8
• Molecular Formula: C₆H₅BrN₂O
• Molecular Weight: 201.02
• Product Categories: ACETYLHALIDE;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 132426-19-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 268.956 °C at 760 mmHg
• Flash Point: 116.461 °C
• Appearance: /
• Density: 1.667 g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.91±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-1-pyrazin-2-ylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-1-pyrazin-2-ylethanone(132426-19-8)
• EPA Substance Registry System: 2-Bromo-1-pyrazin-2-ylethanone(132426-19-8)

Safety Data

• Hazardous Substances Data: 132426-19-8(Hazardous Substances Data)

Usage

Uses

2-Bromo-1-pyrazin-2-ylethanone used for the synthesis of potent 6-heteroaryl-pyrrolidino-tetrahydroisoquinolines with dual histamine H3 antagonist/serotonin transporter inhibitor activity.

InChI:InChI=1/C6H5BrN2O/c7-3-6(10)5-4-8-1-2-9-5/h1-2,4H,3H2

Upstream product

• 22047-25-2 acetylpyrazine 

Downstream Products

• 194282-51-4 Pt((C₆H₅)2PCH₂CH₂P(C₆H₅)2)(S₂C₂HC₄H₃N₂) 
• 917904-52-0 2-{2-[3-(3-morpholin-4-yl-propoxy)-phenyl]-pyrrolidin-1-yl}-1-pyrazin-2-yl-ethanone 
• 1206612-58-9 4-(4-benzyloxycarbonyl-phenyl)-tetrahydro-pyran-4-carboxylic acid 2-oxo-2-pyrazin-2-yl-ethyl ester 
• 194282-49-0 Pd((C₆H₅)2PCH₂CH₂P(C₆H₅)2)(S₂C₂HC₄H₃N₂) 

Relevant articles and documents

Synthesis, Structure and Redox Properties of Asymmetric (Cyclopentadienyl)(ene-1,2-dithiolate)cobalt(III) Complexes Containing Phenyl, Pyridyl and Pyrazinyl Units

The compounds [(η5-C5H5)Co{SC(H)CRS}] [R = phenyl (1), pyridin-3-yl (2) or pyrazin-2-yl (3)] have been synthesized and characterized by elemental analysis, 1H NMR, mass spectrometry and X-ray crystallography. Th

Synthesis and evaluation of the 2-aminothiazoles as anti-tubercular agents

The 2-aminothiazole series has anti-bacterial activity against the important global pathogen Mycobacterium tuberculosis. We explored the nature of the activity by designing and synthesizing a large number of analogs and testing these for activity against M. tuberculosis, as well as eukaryotic cells. We determined that the C-2 position of the thiazole can accommodate a range of lipophilic substitutions, while both the C-4 position and the thiazole core are sensitive to change. The series has good activity against M. tuberculosis growth with sub-micromolar minimum inhibitory concentrations being achieved. A representative analog was selective for mycobacterial species over other bacteria and was rapidly bactericidal against replicating M. tuberculosis. The mode of action does not appear to involve iron chelation. We conclude that this series has potential for further development as novel antitubercular agents.

Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors

A series of novel and potent 6-heteroaryl-pyrrolidino-tetrahydroisoquinolines with dual histamine H3 antagonist/serotonin transporter inhibitor activity is described. In vitro and in vivo data are discussed.