132437-69-5

Upstream product

• 108-55-4 glutaric anhydride, 
• 126017-75-2 4-((S)-1-Phenyl-ethylcarbamoyl)-butyric acid 
• 126017-74-1 (S)-1-(1-phenylethyl)piperidine-2,6-dione 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 132363-91-8 (-)-6-ethoxy-1-((S)-1-phenylethyl)-2-piperidinone 

Downstream Products

• 132363-96-3 (2S)-(-)-2-((2S)-2-hydroxy-2-phenylethyl)-1-((1S)-1-phenylethyl)-2-piperidine 
• 132437-70-8 (2S)-(-)-2-((2R)-2-hydroxy-2-phenylethyl)-1-((1S)-1-phenylethyl)-2-piperidine 

Relevant academic research and scientific papers

ASYMMETRIC SYNTHESIS OF (+)- AND (-)-CONIINES AND (-)-SEDAMINE BY DIASTEREOSELECTIVE ALKYLATION REACTION OF ETHOXYPIPERIDININE

Diastereoselective alkylation reaction of the chiral 6-ethoxypiperidinones (4) and (5) has been developed and successfully applied to the asymmetric synthesis of piperidine alkaloids, (+)- and (-)-coiines (11) and (12), (-)-sedamine (21), and (-)-allosedamine (22).