132442-32-1

Basic information

• Product Name: (1-Benzyl-piperidin-4-yl)-isopropyl-aMine
• Synonyms: (1-Benzyl-piperidin-4-yl)-isopropyl-aMine;1-BENZYL-N-ISOPROPYLPIPERIDIN-4-AMINE
• CAS NO: 132442-32-1
• Molecular Formula: C₁₅H₂₄N₂
• Molecular Weight: 232.36446
• Mol File: 132442-32-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1-Benzyl-piperidin-4-yl)-isopropyl-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Benzyl-piperidin-4-yl)-isopropyl-aMine(132442-32-1)
• EPA Substance Registry System: (1-Benzyl-piperidin-4-yl)-isopropyl-aMine(132442-32-1)

Safety Data

• Hazardous Substances Data: 132442-32-1(Hazardous Substances Data)

Upstream product

• 50541-93-0 4-amino-1-benzylpiperidine 
• 67-64-1 acetone 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 75-31-0 isopropylamine 

Downstream Products

• 534595-53-4 (ii)-Isopropyl-piperidin-4-yl-amine 
• 690999-01-0 N-(1-benzylpiperidin-4-yl)-N-isopropyl-3-(bromopropoxy)propionamide 
• 690999-05-4 N-(1-benzylpiperidin-4-yl)-N-isopropyl-2-chloroacetamide 
• 690998-89-1 1-benzyl-4-(N-tert-butoxycarbonyl-N-isopropylamino)piperidine 
• 179558-63-5 1-benzyl-4-[N-isopropyl-N-(3-ethylamino-2-pyridinyl)amino]piperidine 
• 179558-62-4 N²-(1-Benzyl-piperidin-4-yl)-N²-isopropyl-pyridine-2,3-diamine 
• 179557-06-3 1-benzyl-4-[N-(1-methylethyl)-N-(3-nitro-2-pyridinyl)amino]piperidine 

Relevant articles and documents

Process for preparing substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds

Processes and intermediates for preparing substituted 4-amino-1-(pyridylmethyl)-piperidine and related compounds in high yield and high purity are described. The substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds prepared by the describ

SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL)PIPERIDINE AND RELATED COMPOUNDS

This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.

Targeting delavirdine/atevirdine resistant HIV-1: Identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors

A novel class of bis(heteroaryl)piperazine (BHAP) analogs which possesses the ability to inhibit NNRTI (non-nucleoside reverse transcriptase inhibitor) resistant recombinant HIV-1 reverse transcriptase (RT) and NNRTI resistant variants of HIV-1 has been identified via targeted screening. Further investigation of the structure-activity relationships of close congeners of these novel (alkylamino)piperidine BHAPs (AAP-BHAPs) led to the synthesis of several compounds possessing the desired phenotype (e.g., activity against recombinant RTs carrying the Y181C and P236L substitutions). Further structural modifications were required to inhibit metabolism and modulate solubility in order to obtain compounds with the desired biological profile as well as appropriate pharmaceutical properties. The AAP-BHAPs with the most suitable characteristics were compounds 7, 15, and 36.