132442-35-4Relevant articles and documents
Design and synthesis of N?(benzylpiperidinyl)?4?fluorobenzamide: A haloperidol analog that reduces neuropathic nociception via σ1 receptor antagonism
Déciga-Campos, Myrna,Espinosa-Juárez, Josué,González-Trujano, María Eva,López-Mu?oz, Francisco Javier,Melo-Hernández, Luis Alberto,Navarrete-Vázquez, Gabriel,Schepmann, Dirk,Torres-Gómez, Héctor,Wünsch, Bernhard
, (2020)
Aims: Haloperidol is a neuroleptic drug with high affinity towards the σ1 receptor (σ1R), acting as antagonist that decreases neuropathic pain, but has CNS side effects. This work describes the design and synthesis of a novel analog
2-alkylidene hydroxycumaranone derivatives
-
, (2008/06/13)
Compounds of the formula wherein R,R′, A,B,T and x have the meaning given in the specification possess uPA (urokinase-type plasminogen activator) antagonist activity and can be employed as antitumor and/or antimetastatic agents.