132451-28-6 Usage
General Description
(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methylamine, also known as brexpiprazole, is a chemical compound that belongs to the class of antipsychotic drugs. It acts as a partial agonist at serotonin 5-HT1A and dopamine D2 receptors, and as an antagonist at serotonin 5-HT2A and noradrenaline α1B/2C receptors. Brexpiprazole is used in the treatment of schizophrenia and major depressive disorder (MDD), and has been found to be effective in reducing symptoms of these conditions. It has a unique mechanism of action compared to other antipsychotic medications and is well tolerated with minimal side effects. Brexpiprazole has been approved for medical use in the United States and the European Union.
Check Digit Verification of cas no
The CAS Registry Mumber 132451-28-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,4,5 and 1 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 132451-28:
(8*1)+(7*3)+(6*2)+(5*4)+(4*5)+(3*1)+(2*2)+(1*8)=96
96 % 10 = 6
So 132451-28-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H12N2O/c1-8-10(7-12)13-11(14-8)9-5-3-2-4-6-9/h2-6H,7,12H2,1H3
132451-28-6Relevant articles and documents
Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies
Casimiro-Garcia, Agustin,Bigge, Christopher F.,Davis, Jo Ann,Padalino, Teresa,Pulaski, James,Ohren, Jeffrey F.,McConnell, Patrick,Kane, Christopher D.,Royer, Lori J.,Stevens, Kimberly A.,Auerbach, Bruce J.,Collard, Wendy T.,McGregor, Christine,Fakhoury, Stephen A.,Schaum, Robert P.,Zhou, Hairong
, p. 4883 - 4907 (2008/12/21)
A new series of α-aryl or α-heteroarylphenyl propanoic acid derivatives was synthesized that incorporate acetylene-, ethylene-, propyl-, or nitrogen-derived linkers as a replacement of the commonly used ether moiety that joins the central phenyl ring with
Thiazolidinedione derivatives as hypoglycemic agents
-
, (2008/06/13)
Hypoglycemic thiazolidine-2,4-dione derivatives of the formula wherein the dotted line represents a bond or no bond;, V is -CH=CH-, -N=CH-, -CH=N-, S, O or NR;, W is S, SO, SO2, SO2NR1, NR1SO2, CONR1 or NR1CO;, X is S, O,