Welcome to LookChem.com Sign In|Join Free

CAS

  • or

132463-02-6

Post Buying Request

132463-02-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate

    Cas No: 132463-02-6

  • No Data

  • No Data

  • No Data

  • BOC Sciences
  • Contact Supplier
  • L-Glutamic acid,N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-,1,5-diethyl ester

    Cas No: 132463-02-6

  • No Data

  • No Data

  • No Data

  • Antimex Chemical Limied
  • Contact Supplier

132463-02-6 Usage

General Description

Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate is a complex chemical compound with multiple functional groups. It consists of a diethyl ester group, a quinazoline ring, a methylamino group, a thionyl group, and an L-glutamate moiety. The compound appears to be a derivative of the amino acid glutamate, incorporating a complex structure with potential pharmacological activity. While its specific properties and uses are not immediately clear, further research and analysis of this chemical may reveal its potential applications in medicine and other fields.

Check Digit Verification of cas no

The CAS Registry Mumber 132463-02-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,4,6 and 3 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 132463-02:
(8*1)+(7*3)+(6*2)+(5*4)+(4*6)+(3*3)+(2*0)+(1*2)=96
96 % 10 = 6
So 132463-02-6 is a valid CAS Registry Number.
InChI:InChI=1/C25H30N4O6S/c1-5-34-22(30)12-9-19(25(33)35-6-2)28-24(32)20-10-11-21(36-20)29(4)14-16-7-8-18-17(13-16)23(31)27-15(3)26-18/h7-8,10-11,13,19H,5-6,9,12,14H2,1-4H3,(H,28,32)(H,26,27,31)/t19-/m0/s1

132463-02-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-methylamino]-2-thenoyl]-L-glutamate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:132463-02-6 SDS

132463-02-6Relevant articles and documents

Synthetic method of leraltrexed

-

, (2021/05/05)

The invention provides two method for preparing a compound disclosed as Formula 4. The scheme 1 comprises the following steps: reacting the raw material methyl 5-bromothienyl-2-formate with 6-((methylamino)methyl)-3,4-dihydro-2-methyl-4-oxo-6-quinazoline (compound 1) to obtain methyl 2-[N-(2-methyl-4-oxoquinazolinyl-6-methyl)-N-methyl]-aminothienyl-2-formate, hydrolyzing in an alkaline water solution, and carrying out condensation reaction with diethyl L-glutamate to obtain the compound disclosed as Formula 4. The scheme 2 comprises the following steps: carrying out condensation on the raw material 5-bromothienyl-2-formic acid and di L-glutamate to obtain diethyl N-(5-bromothienyl-2-yl)glutamate, and reacting with a compound disclosed as Formula 1 to obtain the compound disclosed as Formula 4. The invention also provides a method for preparing raltitrexed, which comprises the following steps: hydrolyzing the compound disclosed as Formula 4 in an alkaline water solution, and acidifying with hydrochloric acid to obtain the raltitrexed. The synthesis route has the advantages of fewer reaction steps, low environmental pollution and high product yield, and is simple to operate.

Raltitrexed pharmaceutical composition and preparation method thereof

-

, (2018/04/02)

The invention relates to a raltitrexed pharmaceutical composition which is high in safety and a preparation method thereof. The raltitrexed pharmaceutical composition comprises raltitrexed and thiophene related substances, wherein the content of the thiophene related substances is not higher than 0.3%. The raltitrexed pharmaceutical composition is good in safety, effectiveness and stability and can relieve the blood toxicity of the raltitrexed to a certain degree.

New synthesis of thymidylate synthase inhibitor raltitrexed

Cao, Sheng-Li,Wan, Rong,Feng, Yu-Ping

, p. 3519 - 3526 (2007/10/03)

The quinazoline-based inhibitor of thymidylate synthase, Raltitrexed, was synthesized from 2,5-thiophenedicarboxylic acid via monocoupling with diethyl L-glutamate, modified Curtius reaction, N-methylation, removal of Boc-protecting group, condensation with (bromomethyl)quinazolinone and saponification in 18.2% overall yield.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 132463-02-6