132464-93-8Relevant articles and documents
Knoevenagel condensation catalyzed by sodium silicate under solvent-free conditions
Liu, Qing,Han, Yinfeng
, p. 2033 - 2037 (2011)
Sodium silicate pentahydrate has been utilized as an efficient catalyst for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds to afford substituted olefins in yields of 80.6%～98.9% under solvent-free conditions at room tem
An easy-to-use heterogeneous catalyst for the knoevenagel condensation
Siebenhaar,Casagrande,Studer,Blaser
, p. 566 - 569 (2001)
Physical mixtures of alkali and earth alkali metal carbonates and commercially available zeolites were investigated as solid catalysts for the Knoevenagel condensation. Best results for the model reaction between benzaldehyde and ethyl cyanoacetate were o
Zinc chloride as a new catalyst for Knoevenagel condensation
Shantan Rao,Venkataratnam
, p. 5821 - 5822 (1991)
The Knoevenagel condensation of carbonyl substrates with acidic methylene reagents proceeds smoothly in presence of zinc chloride, without the need for solvent, to produce products of good purity in high yield.
Vanadium-Catalyzed Condensation of Ethyl Cyanoacetate with Ketones
Khusnutdinov,Shchadneva,Mayakova, Yu. Yu.
, p. 403 - 409 (2018)
Vanadium compounds and complexes activated by pyridine or morpholine catalyze condensation of ethyl cyanoacetate with ketones and aldehydes leading to alkylidenecyanoacetates in 75–100% yield.
Microwave assisted Knoevenagel condensation using sodium fluoride and lithium chloride as catalysts under solvent-free conditions
Mogilaiah,Prashanthi,Reddy, G. Randheer,Reddy, Ch. Srinivas,Reddy, N. Vasudeva
, p. 2309 - 2312 (2003)
Microwave assisted Knoevenagel condensation of aromatic aldehydes 1 with active methylene compounds 2 under solvent free conditions to prepare arylidene compounds 3 in excellent yields using cheap and readily available NaF and LiCI as catalysts has been d
Covalently anchored tertiary amine functionalized ionic liquid on silica coated nano-Fe3O4 as a novel, efficient and magnetically recoverable catalyst for the unsymmetrical Hantzsch reaction and Knoevenagel condensation
Zhang, Qiang,Ma, Xiao-Ming,Wei, Huai-Xin,Zhao, Xin,Luo, Jun
, p. 53861 - 53870 (2017)
A novel magnetic nanoparticle supported basic ionic liquid was successfully prepared by covalently anchoring 1-(2′-piperidyl)ethyl-3-(3-propyltriethoxysilane)imidazolium chloride onto the surface of silica-coated Fe3O4 nanoparticles, and characterized by FT-IR, TEM, XRD, TGA, VSM and elemental analysis. The obtained supported ionic liquid was certified as a versatile and robust catalyst for the unsymmetrical Hantzsch reaction and Knoevenagel condensation under solvent-free conditions. Furthermore, the catalyst could be conveniently recovered by an external magnet and reused six times without significant loss of catalytic activity.
Photoprotective effect and acute oral systemic toxicity evaluation of the novel heterocyclic compound LQFM048
Vinhal, Daniela C.,De ávila, Renato Ivan,Vieira, Marcelo S.,Luzin, Rangel M.,Quintino, Michelle P.,Nunes, Liliane M.,Ribeiro, Antonio Carlos Chaves,De Camargo, Henrique Santiago,Pinto, Angelo C.,Dos Santos Júnior, Helvécio M.,Chiari, Bruna G.,Isaac, Vera,Valadares, Marize C.,Martins, Tatiana Duque,Li?o, Luciano M.,De Gil, Eric S.,Menegatti, Ricardo
, p. 50 - 58 (2016)
The new heterocyclic derivative LQFM048 (3) (2,4,6-tris ((E)-ethyl 2-cyano-3-(4-hydroxy-3-methoxyphenyl)acrylate)-1,3,5-triazine) was originally designed through the molecular hybridization strategy from Uvinul T 150 (1) and (E)-ethyl 2-cyano-3-(4hydroxy-
Efficient green procedure for the Knoevenagel condensation under solvent-free conditions
Rong, Liangce,Li, Xiaoyue,Wang, Haiying,Shi, Daqing,Tu, Shujiang,Zhuang, Qiya
, p. 2407 - 2412 (2006)
Knoevenagel condensation of aromatic aldehydes with active methylene compounds under solvent-free conditions to synthesize arylidene compounds by grinding in the presence of TEBA at room temperature has been described. This method is simple, efficient, an
Bismuth (III) Triflate: A Mild, Efficient Promoter for the Synthesis of Trisubstituted Alkenes through Knoevenagel Condensation
Datta, Arup
, p. 843 - 849 (2020/11/25)
In this work, smooth efficient and eco-friendly two component coupling method is reported for the synthesis of Knoevenagel Condensation product in presence of Bi(OTf)3 catalyst under solvent free condition. Catalyst has participated in condensation between substituted aldehydes (aromatic and hetero-aromatic) and active methylene compounds (ethyl cyanoacetate, malononitrile and cyanoacetamide) effectively to generate an excellent yield of the product. Bi(OTf)3 catalyst is stable, inexpensive and easily available was used for four times in this reaction without loss of catalytic activity. [Formula Presented]
Overcoming acid–base copolymer neutralization using mesoporous carbon and its catalytic activity in the tandem deacetalization–Knoevenagel condensation reaction
Javad Kalbasi, Roozbeh,Rahmati, Fatemeh,Mazaheri, Omid
, p. 3413 - 3430 (2020/05/16)
Abstract: Acid–base copolymer materials are of considerable interest because of their fundamental implications for acid–base bifunctional catalysis applications. However, quenching the acid and base sites of the copolymer with each other in free radical polymerizations is still challenging. Herein, we demonstrate that the polymerization of styrenesulfonic acid-co-4-vinylpyridine into the mesoporous carbon material (i.e., CMK-3) can control the chain growth polymerization and result in decreasing the interaction of the acid–base sites. The results showed that by using CMK-3, 40% of the acid and base sites of the copolymer remain in their original form while 60% of acid and base sites convert to the pyridinium and sulfonate forms. Furthermore, it is demonstrated that this material can be processed as a heterogeneous bifunctional acid–base catalyst in the tandem one-pot acid–base reaction (i.e., deacetalization–Knoevenagel condensation reaction) with a high catalytic activity in aqueous media. Graphic abstract: [Figure not available: see fulltext.].
