132465-62-4 Usage
Chemical class
Pyrazole derivative
Functional group
Carboxylic acid
Pharmacological applications
Potential anti-inflammatory agent, building block for other pharmaceutical compounds, potential treatment for neurological disorders
Structure
The compound consists of a pyrazole ring fused to a dihydro ring, with two phenyl groups attached to the first and fifth positions of the pyrazole ring
Research focus
Medicinal chemistry, therapeutic applications
Investigation
Studied for its potential role in treating inflammation, neurological disorders, and as a precursor for other pharmaceutical compounds
Molecular weight
Approximately 277.32 g/mol
Appearance
Likely a solid, though specific appearance may vary depending on the form (e.g., crystalline, amorphous)
Solubility
Solubility information is not provided in the material, but carboxylic acids generally have some solubility in water and are more soluble in organic solvents like ethanol or methanol
Stability
Stability information is not provided in the material, but pyrazole derivatives are generally stable under normal conditions
Synthesis
The synthesis of 1,5-diphenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid typically involves the formation of the pyrazole ring and subsequent functionalization with the carboxylic acid group and phenyl groups
Reactivity
As a carboxylic acid, it can undergo reactions such as esterification, amide formation, and other carboxylic acid-specific reactions. The pyrazole ring may also participate in various reactions, depending on the substituents and reaction conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 132465-62-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,4,6 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 132465-62:
(8*1)+(7*3)+(6*2)+(5*4)+(4*6)+(3*5)+(2*6)+(1*2)=114
114 % 10 = 4
So 132465-62-4 is a valid CAS Registry Number.
132465-62-4Relevant articles and documents
Diaryl dihydropyrazole-3-carboxamides with significant in vivo antiobesity activity related to CB1 receptor antagonism: Synthesis, biological evaluation, and molecular modeling in the homology model
Srivastava, Brijesh Kumar,Joharapurkar, Amit,Raval, Saurin,Patel, Jayendra Z.,Soni, Rina,Raval, Preeti,Gite, Archana,Goswami, Amitgiri,Sadhwani, Nisha,Gandhi, Neha,Patel, Harilal,Mishra, Bhupendra,Solanki, Manish,Pandey, Bipin,Jain, Mukul R.,Patel, Pankaj R.
, p. 5951 - 5966 (2008/04/12)
A number of analogues of diaryl dihydropyrazole-3-carboxamides have been synthesized. Their activities were evaluated for appetite suppression and body weight reduction in animal models. Depending on the chemical modification of the selected dihydropyrazole scaffold, the lead compounds - the bisulfate salt of (±)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazole-3- carboxylic acid morpholin-4-ylamide 26 and the bisulfate salt of (-)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazole-3- carboxylic acid morpholin-4-ylamide 30-showed significant body weight reduction in vivo, which is attributed to their CB1 antagonistic activity and exhibited a favorable pharmacokinetic profile. The molecular modeling studies also showed interactions of two isomers of (±)-5-(4-chlorophenyl)-1-(2,4- dichlorophenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid morpholin-4-ylamide 9 with CB1 receptor in the homology model similar to those of N-piperidino-5-(4- chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazole-carboxamide (rimonabant) 1 and 4S-(-)-3-(4-chlorophenyl)-N-methyl-N′-[(4-chlorophenyl) -sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamidine (SLV-319) 2.
