132472-31-2 Usage
General Description
"(3E)-2-amino-4-(phosphonomethyl)hept-3-enoic acid" is a chemical compound that is also known as APH. It is a highly potent and selective inhibitor of glutamate carboxypeptidase II (GCPII), an enzyme that plays a role in the regulation of glutamate levels in the central nervous system. APH has shown promise in the treatment of neurological disorders such as neuropathic pain and neurodegenerative diseases. It is also being investigated for its potential use in cancer therapy. Additionally, APH has been studied for its potential role as a neuroprotective agent and as a treatment for cognitive impairment. Overall, this compound has demonstrated diverse pharmacological properties and has the potential to be a valuable tool in the development of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 132472-31-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,4,7 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 132472-31:
(8*1)+(7*3)+(6*2)+(5*4)+(4*7)+(3*2)+(2*3)+(1*1)=102
102 % 10 = 2
So 132472-31-2 is a valid CAS Registry Number.
132472-31-2Relevant articles and documents
Unsaturated amino acids
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, (2008/06/13)
The invention relates to unsaturated amino acids of the formula I STR1 in which R1 represents hydroxy or etherified hydroxy, R2 represents hydrogen, alkyl, hydroxy or etherified hydroxy, R3 represents hydrogen, alkyl, haloalkyl, hydroxyalkyl, lower alkoxyalkyl, arylalkyl, lower alkenyl, halogen or aryl, R4 represents hydrogen, alkyl or aryl, R5 represents hydrogen or alkyl, R6 represents carboxy or esterified or amidated carboxy, R7 represents amino or amino substituted by alkyl or acyl, A represents unsubstituted or alkyl-substituted α,ω-alkylene having from 1 to 3 carbon atoms or represents a bond, and B represents methylene or a bond, with the proviso that A is other than a bond when B represents a bond, and salts thereof. They can be manufactured, for example, in accordance with the Michaelis-Arbuzov reaction and can be used as pharmacologically active substances.