132486-22-7Relevant academic research and scientific papers
Jalapinoside II, a bisdesmoside resin glycoside, and related glycosidic acids from the officinal jalap root (Ipomoea purga)
Bautista, Elihú,Fragoso-Serrano, Mabel,Pereda-Miranda, Rogelio
, p. 85 - 93 (2016)
Jalapinoside II, a macrocyclic bidesmoside resin glycoside with purgic acid C as its oligosaccharide core, was isolated by recycle preparative-scale HPLC from the MeOH-soluble extract of Ipomoea purga (Convolvulaceae), the officinal jalap root (“Rhizoma Jalapae”). This study also reports the complete NMR data assignment for purgic acid C and the structural elucidation of purgic acid D, both glycosidic acids were isolated, in conjunction with previously known purgic acids A and B, under saponification of the MeOH-soluble resin glycosides. HPLC and 13C NMR profiles were used as analytical tools for the authentication of the commercialized Mexican scammony resin. Reversal factor of multidrug resistance by the non-cytotoxic jalapinoside II was evaluated in vinblastine-resistant human breast carcinoma cells (RFMCF-7/Vin+ > 1906).
