13249-01-9

Basic information

• Product Name: 1-phenyl-3-pyrimidin-2-ylthiourea
• CAS NO: 13249-01-9
• Molecular Formula: C₁₁H₁₀N₄S
• Molecular Weight: 230.2889
• Mol File: 13249-01-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 400.6°C at 760 mmHg
• Flash Point: 196.1°C
• Density: 1.402g/cm³
• Vapor Pressure: 1.26E-06mmHg at 25°C
• Refractive Index: 1.774
• CAS DataBase Reference: 1-phenyl-3-pyrimidin-2-ylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-3-pyrimidin-2-ylthiourea(13249-01-9)
• EPA Substance Registry System: 1-phenyl-3-pyrimidin-2-ylthiourea(13249-01-9)

Safety Data

• Hazardous Substances Data: 13249-01-9(Hazardous Substances Data)

Usage

Class

Thioureas

Biological activities

Diverse, including potential pharmacological properties

Pharmacological properties

Inhibition of cancer cell growth, anti-inflammatory effects, anti-diabetic effects

Other potential benefits

Protection against oxidative stress and neurodegenerative diseases

Unique features

Interesting structure and potential medicinal properties for further research and development.

Upstream product

• 109-12-6 2-aminopyrimidine 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 58930-42-0 2-phenylimino-3-pyrimidin-2-yl-thiazolidin-4-one 
• 1205532-91-7 CuBr(N-(2-pyrimidyl)-N'-phenylthiourea)2 
• 1205532-90-6 CuCl(N-(2-pyrimidyl)-N'-phenylthiourea)2 
• 315705-35-2 [4-(3,4-dimethoxyphenyl)-thiazol-2-yl]-pyrimidin-2-yl-amine 
• 31437-20-4 pyrimidin-2-yl-thiourea 
• 1279716-61-8 [4-(4-methoxyphenyl)-3-phenyl-3H-thiazol-2-ylidene]pyrimidin-2-ylamine 
• 1279716-60-7 [4-(4-chlorophenyl)-3-phenyl-3H-thiazol-2-ylidene]pyrimidin-2-ylamine 
• 1053662-46-6 [4-(4-tolyl)-3-phenyl-3H-thiazol-2-ylidene]pyrimidin-2-ylamine 

Relevant articles and documents

Synthesis and anticancer evaluation of novel triazole linked N-(pyrimidin-2-yl)benzo[d]thiazol-2-amine derivatives as inhibitors of cell survival proteins and inducers of apoptosis in MCF-7 breast cancer cells

A series of novel triazole linked N-(pyrimidin-2yl)benzo[d]thiazol-2-amine 5a-k were synthesized and evaluated for anticancer activity against breast (MCF-7), lung (A549) and skin (A375) cancer cell lines and their cytotoxic effects were compared against

Diversity-Oriented Synthesis of Thiazolidine-2-imines via Microwave-Assisted One-Pot, Telescopic Approach and Its Interaction with Biomacromolecules

In this work, a one-pot, telescopic approach is described for the combinatorial library of thiazolidine-2-imines. The synthetic manipulation proceeds smoothly via the reaction of 2-aminopyridine/pyrazine/pyrimidine with substituted isothiocyanates followed by base catalyzed ring closure with 1,2-dibromoethane to obtain thiazolidine-2-imines with broad substrate scope and high functional group tolerance. The synthetic strategy merges well with the thiourea formation followed by base catalyzed ring closure reaction for the thiazolidine-2-imine synthesis in a more modular and straightforward approach. The synthetic procedure reported herein represents a cleaner route toward thiazolidine-2-imines as compared to traditional methodologies. Moreover, the biological significance of combinatorially synthesized thiazolidin-2-imines has been investigated for their use as possible inhibitors for acetyl cholinesterase through molecular docking studies.

Synthesis and antiviral activity of some (3,4-diaryl-3H-thiazol-2-ylidene) pyrimidin-2-yl amine derivatives

Chemical Equation Presented Thirteen new (3,4-diaryl-3H-thiazol-2-ylidene) pyrimidin-2-yl amine derivatives were synthesized by reacting 1-aryl-3-pyrimidin-2-yl-thiourea derivatives and phenacyl bromides in absolute ethanol. The solid that separated was f