132490-10-9Relevant academic research and scientific papers
Efficient synthesis of a novel m-phenylene derivative as a selective EP4 agonist inducing follicular growth and maturation in the ovary
Hayashi, Ryoji,Hosono, Yutaka,Nakatsuji, Koji,Tanaka, Yoichiro,Mori, Takeshi,Kanno, Takami,Makita, Kei,Moriwaki, Mitsuhiro,Ohyama, Tomofumi,Ochi, Yasuo,Inada, Chifumi,Isogaya, Masafumi
, p. 7505 - 7508 (2011)
An efficient and straightforward synthesis of a novel m-phenylene derivative has been developed. The optically pure dibromo compound was selected as a starting material. Through a protocol involving the Prins reaction and two steps of the Horner-Wadsworth-Emmons reaction, the basic skeleton was constructed with appropriate alpha and omega side chains. The compound proved to be a highly selective EP4 agonist and a possible drug candidate for maturation of the uterine cervix.
Total synthesis of optically active m-phenylene PGl2 derivative: Beraprost
Wakita, Hisanori,Yoshiwara, Hideo,Nishiyama, Hisao,Nagase, Hiroshi
, p. 1085 - 1110 (2007/10/03)
The optical isomers of m-phenylene PGl2 derivative, Beraprost, were synthesized in practical scales from optically active carboxy- cyclopenta[b]benzofurans (12 and 13) by Wittig and Wadsworth reactions as key reactions via the intermediate diols (16a and 16b).
