132497-46-2

Upstream product

• 74226-00-9 ethyl 4-(3-bromopropoxy)benzoate 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 132497-47-3 4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-propoxy]-benzoic acid ethyl ester 
• 132497-49-5 diethyl N-<4-<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propoxy>benzoyl>-L-glutamate 
• 132497-48-4 4-<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propoxy>benzoic acid 

Relevant academic research and scientific papers

Synthesis and biological activity of open-chain analogues of 5,6,7,8- tetrahydrofolic acid-potential antitumor agents

This study describes the synthesis and in vitro antitumor activity of inhibitors of purine de novo biosynthesis that are analogues of N-[4-[[3- (2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl-L-glutamic acid (5-DACTHF). Benzene ring subs