132499-48-0Relevant academic research and scientific papers
Compounds with Bridgehead Nitrogen
Crabb, Trevor A.,Roch, Olive G.,Robinson, Paul
, p. 1069 - 1072 (1986)
In contrast to the reported reaction between trans-1-aminotetralin-2-ol and formaldehyde, which gives r-6a,c-9a,t-15a,t-18a-5,6,6a,9a,14,15,15a,18a-octahydro-9,18-methanodinaphthodioxadiazecine, an examination of the δ 4.0-5.0 region of the 1H NMR spectra of the products of the reaction between trans-3-aminotetralin-2-ol and formaldehyde showed these to be a 50:50 mixture of r-5a,t-8a,c-14a,t-17a- and r-5a,c-8a,t-14a,t-17a-5,5a,8a,9,14,14a,17a,18-octahydro-8,17-methanodinaphthodioxadiazecine.In a similar way, the reaction between trans-2-aminocyclohexanol and formaldehyde was reexamined and found to produce initially a ca 80:20 mixture of r-4a,t-7a,c-11a,t-14a- and r-4a,c-7a,t-11a,t-14a-7,14-methanoperhydrodibenzodioxadiazecines. KEY WORDS Octahydro-8,17-methanodinaphthodioxadiazecine 7,14-Methanoperhydrodibenze>1,6,3,8>dioxadiazecines 1H NMR Geminal coupling constants trans-3-Aminotetralin-2-ol
2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
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Page/Page column 26, (2010/11/08)
Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor therapy such as diabetes and related conditions (such as hy
