13252-30-7

Basic information

• Product Name: 1-[(4-Nitrophenyl)]-3-(pyridin-4-yl)urea
• Synonyms: 1-[(4-Nitrophenyl)]-3-(pyridin-4-yl)urea
• CAS NO: 13252-30-7
• Molecular Formula: C₁₂H₁₀N₄O₃
• Molecular Weight: 258.2328
• Mol File: 13252-30-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[(4-Nitrophenyl)]-3-(pyridin-4-yl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-Nitrophenyl)]-3-(pyridin-4-yl)urea(13252-30-7)
• EPA Substance Registry System: 1-[(4-Nitrophenyl)]-3-(pyridin-4-yl)urea(13252-30-7)

Safety Data

• Hazardous Substances Data: 13252-30-7(Hazardous Substances Data)

Upstream product

• 504-24-5 4-aminopyridine 
• 100-28-7 4-Nitrophenyl isocyanate 

Downstream Products

• 124421-19-8 N-(4-aminophenyl)-N'-(4-pyridinyl)urea hydrochloride 

Relevant articles and documents

Substituent effect of N-aryl-N′-pyridyl ureas as thermal latent initiators on ring-opening polymerization of epoxide

A series of N-aryl-N′-pyridyl ureas were synthesized by the reactions of 4-aminopyridine (4AP) with the corresponding isocyanates such as phenyl isocyanate, 4-methylphenyl isocyanate, 4-methoxyphenyl isocyanate, 4-chlorophenyl isocyanate, 4-(trifluorometh

N-phenyl-N'-pyridinylureas as anticonvulsant agents

A series of N-phenyl-N'-pyridinylureas was examined for anticonvulsant activity. Extensive structure/activity investigations revealed optimal activity in the N-(2,6-disubstituted-phenyl)-N'-(4-pyridinyl)urea series, with 37 exhibiting the best overall anticonvulsant profile. Compound 37 was effective against seizures induced by maximal electroshock but did not protect mice from clonic seizures produced by the convulsant pentylenetetrazol. The overall pharmacological profile suggests that 37 would be of therapeutic use in the treatment of generalized tonic-clonic and partial seizures. Compound 37 was selected for Phase 1 clinical trials.