13252-84-1Relevant articles and documents
Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists
Kym, Philip R.,Iyengar, Rajesh,Souers, Andrew J.,Lynch, John K.,Judd, Andrew S.,Gao, Ju,Freeman, Jennifer,Mulhern, Mathew,Zhao, Gang,Vasudevan, Anil,Wodka, Dariusz,Blackburn, Christopher,Brown, Jim,Che, Jennifer Lee,Cullis, Courtney,Lai, Su Jen,LaMarche, Matthew J.,Marsilje, Tom,Roses, Jon,Sells, Todd,Geddes, Brad,Govek, Elizabeth,Patane, Michael,Fry, Dennis,Dayton, Brian D.,Brodjian, Sevan,Falls, Doug,Brune, Michael,Bush, Eugene,Shapiro, Robin,Knourek-Segel, Victoria,Fey, Thomas,McDowell, Cathleen,Reinhart, Glenn A.,Preusser, Lee C.,Marsh, Kennan,Hernandez, Lisa,Sham, Hing L.,Collins, Christine A.
, p. 5888 - 5891 (2005)
4-(1-Benzo[1,3]dioxol-5-ylmethylpiperidine-4-ylmethyl)-6-chlorochromen-2- one (7) is a potent, orally bioavailable melanin concentrating hormone receptor 1 (MCHr1) antagonist that causes dose-dependent weight loss in diet-induced obese mice. Further evalu
Copper(II)-Catalyzed Tandem Reaction: Synthesis of Furo[3,2- c]coumarin Derivatives and Evaluation for Photophysical Properties
Feng, Xi,Qin, Zhen,Cheng, Xinying,Liu, Dongyu,Peng, Yinghe,Huang, Huidan,Song, Bin,Bian, Jinlei,Li, Zhiyu
supporting information, p. 12537 - 12548 (2021/09/20)
An efficient protocol for synthesizing furo[3,2-c]coumarin derivatives is described. The novel reaction could afford the desired furocoumarins with good to excellent yields in a mild and rapid manner. Large substrate scope screening and scale-up preparation have also been accomplished, and selected compounds were evaluated for their photophysical properties.
Synthesis and biological evaluation of bis-N2,N2′-(4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccinodihydrazides
Hoppe, Heinrich C.,Isaacs, Michelle,Kaye, Perry T.,Krause, Rui W. M.,Manyeruke, Meloddy H.,Seldon, Ronnett,Tshiwawa, Thendamudzimu,Warner, Digby F.
, (2020/01/22)
A series of N2,N2′-bis[4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccino-hydrazides, containing 4-hydroxycoumarin, hydrazine and tartaric acid moieties, have been prepared and examined for possible biological activity. Several of these compounds exhibit promising HIV-1 integrase inhibition (IC50 = 3.5 μM), and anti-T. brucei (32% viability) and anti-mycobacterial (Visual MIC90 = 15.63 μM) activity.