132521-67-6

Basic information

• Product Name: 4-Amino-2-chloroquinoline
• Synonyms: 2-chloro-3-nitroquinolin-4-amine
• CAS NO: 132521-67-6
• Molecular Formula: C9H7ClN2
• Molecular Weight: 178.61828
• Mol File: 132521-67-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Amino-2-chloroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-2-chloroquinoline(132521-67-6)
• EPA Substance Registry System: 4-Amino-2-chloroquinoline(132521-67-6)

Safety Data

• Hazardous Substances Data: 132521-67-6(Hazardous Substances Data)

Upstream product

• 132521-66-5 2,4-dichloro-3-nitroquinoline 
• 70254-44-3 2,4-dihydroxyquinoline 
• 15151-57-2 2,4-dihydroxy-3-nitroquinoline 

Relevant articles and documents

Design, synthesis and biological evaluation of benzyloxyphenyl-methylaminophenol derivatives as STAT3 signaling pathway inhibitors

STAT3 signaling pathway has been validated as a vital therapeutic target for cancer therapy. Based on the novel STAT3 inhibitor of a benzyloxyphenyl-methylaminophenol scaffold hit (1) discovered through virtual screening, a series of analogues had been designed and synthesized for more potent inhibitors. The preliminary SAR had been discussed and the unique binding site in SH2 domain was predicted by molecular docking. Among them, compounds 4a and 4b exhibited superior activities than hit compound (1) against IL-6/STAT3 signaling pathway with IC50 values as low as 7.71 μM and 1.38 μM, respectively. Compound 4a also displayed potent antiproliferative activity against MDA-MB-468 cell line with an IC50 value of 9.61 μM. We believe that these benzyloxyphenyl-methylaminophenol derivatives represent a unique mechanism for interrogating STAT3 as well as a potential structure type for further exploration.

1H-imidazo?4,5-c!quinolin-4-amines

Novel 1H-imidazo?4,5-c!quinolin-4-amines are disclosed. The compounds function as antiviral agents and they are potential synthetic intermediates in the preparation of known antiviral agents and labeled known antiviral agents. Processes for the preparation of the compounds, methods for their antiviral use, and methods of inducing interferon biosynthesis, are also described.