132521-78-9

Basic information

• Product Name: 6-(1-Piperazinyl)-3-pyridinecarboxylic acid ethyl ester
• Synonyms: 6-(1-Piperazinyl)-3-pyridinecarboxylic acid ethyl ester
• CAS NO: 132521-78-9
• Molecular Formula: C₁₂H₁₇N₃O₂
• Molecular Weight: 235.28
• Product Categories: pharmacetical
• Mol File: 132521-78-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 405.3°Cat760mmHg
• Flash Point: 198.9°C
• Appearance: /
• Density: 1.145g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-(1-Piperazinyl)-3-pyridinecarboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(1-Piperazinyl)-3-pyridinecarboxylic acid ethyl ester(132521-78-9)
• EPA Substance Registry System: 6-(1-Piperazinyl)-3-pyridinecarboxylic acid ethyl ester(132521-78-9)

Safety Data

• Hazardous Substances Data: 132521-78-9(Hazardous Substances Data)

Usage

General Description

6-(1-Piperazinyl)-3-pyridinecarboxylic acid ethyl ester, also known as etazene, is a chemical compound that belongs to the class of pyridinecarboxylic acid esters. It is often used as a pharmaceutical intermediate in the synthesis of various drugs due to its ability to act as a ligand for a range of different receptors. Etazene has been studied for its potential as a treatment for various conditions, including psychiatric disorders and neurological diseases. Additionally, it has been investigated for its potential as an analgesic and anxiolytic agent. However, further research is needed to fully understand its pharmacological effects and potential therapeutic applications.

InChI:InChI=1/C12H17N3O2/c1-2-17-12(16)10-3-4-11(14-9-10)15-7-5-13-6-8-15/h3-4,9,13H,2,5-8H2,1H3

Upstream product

• 49608-01-7 6-chloro-3-pyridinecarboxylic acid ethyl ester 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 110-85-0 piperazine 

Downstream Products

• 1204976-90-8 ethyl 6-(4-(6-(4-fluorobenzyl)-4,5-dimethylpyridazin-3-yl)piperazin-1-yl)nicotinate 
• 1310536-91-4 ethyl 6-(4-(phenylcarbamoyl)piperazin-1-yl)nicotinate 
• 1057677-65-2 6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]nicotinic acid ethyl ester 
• 944541-40-6 C₂₂H₂₆FN₃O₃ 

Relevant articles and documents

Anthranilic acid amide compound and its preparation and use

The invention belongs to the field of drug synthesis and relates to an anthranilamide compound with the general formula (I), in particular to an anthranilamide compound containing piperidine or piperazine, and pyridine analogues, a preparation method and medical application of the anthranilamide compound and the pyridine analogues. According to the compound, through a target gene Gli inhibitory activity test in an in-vitro Hedgehog signal pathway, a result shows that the compound has good Hedgehog signal pathway inhibitory activity, and a new antitumor drug can further be prepared. (Please see the formula in the specification).

PROLINE DERIVATIVES AND USE THEREOF AS DRUGS

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.