132522-81-7

Basic information

• Product Name: 5-Nitro-2H-1,4-benzoxazin-3(4H)-one
• Synonyms: 5-Nitro-2H-1,4-benzoxazin-3(4H)-one;5-NITRO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE;5-Nitro-3,4-dihydro-2H-1,4-benzoxazin-3-one;5-Nitro-4H-benzo[1,4]oxazin-3-one
• CAS NO: 132522-81-7
• Molecular Formula: C₈H₆N₂O₄
• Molecular Weight: 194.145
• Product Categories: Benzomorpholines & Benzothiomorpholines
• Mol File: 132522-81-7.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Nitro-2H-1,4-benzoxazin-3(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Nitro-2H-1,4-benzoxazin-3(4H)-one(132522-81-7)
• EPA Substance Registry System: 5-Nitro-2H-1,4-benzoxazin-3(4H)-one(132522-81-7)

Safety Data

• Hazardous Substances Data: 132522-81-7(Hazardous Substances Data)

Usage

General Description

5-Nitro-2H-1,4-benzoxazin-3(4H)-one is a highly potent bioactive compound that has generated significant interest in pharmaceutical and medicinal research due to its potential therapeutic properties. It is an organic cyclic compound which possesses the unique structural properties of the benzoxazinone class, characterized by a benzene ring fused with a nitrogen and an oxygen heterocyclic ring. 5-Nitro-2H-1,4-benzoxazin-3(4H)-one has been explored for its potential anti-microbial, anti-bacterial, anti-inflammatory, and anti-cancer activities. Therefore, the synthesis and further research of 5-Nitro-2H-1,4-benzoxazin-3(4H)-one could be instrumental in the development of new and effective pharmaceutical drugs.

Upstream product

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Downstream Products

• 1338064-97-3 2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide 
• 1338064-82-6 1-(4-(trifluoromethyl)-2-(piperidin-1-yl)benzyl)-3-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)urea 
• 1338064-81-5 1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)urea 
• 1338064-80-4 1-(4-(trifluoromethyl)benzyl)-3-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)urea 
• 132522-83-9 5-Amino-3,4-dihydro-4-methyl-2H-1,4-benzoxazin-3-one 
• 148890-63-5 5-amino-4H-benz[1,4]oxazin-3-one 

Relevant articles and documents

"TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION"

The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active

ALKYL-SUBSTITUTED 3' COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, Ar, m and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

ACYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): wherein R1, R2, R5, Q, G, Ar, m, and n are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.