132533-03-0

Upstream product

• 54976-37-3 3-phenylbut-2-en-1-ol 
• 945-93-7 ethyl (E)-3-phenylbut-2-enoate 
• 54976-38-4 (E)-3-phenylbut-2-en-1-ol 

Downstream Products

• 132533-04-1 3,3-Dimethyl-6-(1-phenyl-vinyl)-[1,2,4]trioxane 
• 1415548-72-9 C₃₅H₅₀O₅ 
• 868696-20-2 succinic acid mono-[3-(1-phenyl-vinyl)-1,2,5-trioxa-spiro[5.5]undec-9-yl] ester 
• 868696-29-1 2-[3-(1-phenylvinyl)-1,2,5-trioxaspiro[5.5]undec-9-ylidene]propionic acid ethyl ester 
• 868696-27-9 [3-(1-phenyl-vinyl)-1,2,5-trioxa-spiro[5.5]undec-9-ylidene]-acetic acid ethyl ester 
• 868696-17-7 3-(1-phenyl-vinyl)-1,2,5-trioxa-spiro[5.5]undecan-9-ol 
• 678967-25-4 3-(1-Phenyl-vinyl)-1,2,5-trioxaspiro[5.5]undec-9-one 
• 132533-06-3 (3R,6R)-3-(4-Methoxy-phenyl)-6-(1-phenyl-vinyl)-[1,2,4]trioxane 
• 132533-05-2 3-(1-Phenyl-vinyl)-1,2,5-trioxa-spiro[5.5]undecane 

Relevant academic research and scientific papers

Bile acid-based 1,2,4-trioxanes: Synthesis and antimalarial assessment(1)

A new series of bile acid-based trioxanes 23a-d, 24a-d, 25a-d, 26a, 26b, and 26d have been synthesized and assessed for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route. The antimalarial activity of these trioxanes showed a strong dependence on the side-chain length; shortening side-chain length lead to increase in activity. The antimalarial activity also showed even stronger dependence on the stereochemistry at C3 and C6 (C21 in Figure 5) of the trioxane moiety. Of the two diastereomers isolated of each of the trioxanes, more polar one was significantly more active than the less polar one. The more polar diastereomer of the trioxanes 26a, 26b, and 26d, were the most active compounds of the series. All these three trioxanes provided 100% protection at 24 mg/kg × 4 days. In this model β-arteether provided 100% and 20% protection at 48 mg/kg × 4 days and 24 mg/kg × 4 days, respectively.

Orally active antimalarials: Synthesis and bioevaluation of a new series of steroid-based 1,2,4-trioxanes against multi-drug resistant malaria in mice

A new series of steroid-based 1,2,4-trioxanes 7a-f, 8a-f and 9b-e have been synthesized and evaluated for their antimalarial activity against multi-drug resistant Plasmodium yoelii in Swiss mice by oral route. The biological activity shows a strong depend

SPIRO-1,2,4-TRIOXANES AS ANTIMALARIAL AGENTS

The present invention provides novel spiro trioxane series of general Formula (4). This invention also provides a process for the preparation of novel spiro trioxane series. These novel spiro-trioxane cmpounds useful as anti-malarial agents.

Novel spiro-1,2,4-trioxanes

The present invention relates to spiro 1,2,4-trioxanes of general formula 4. This invention more particularly relates to a process for the preparation of a series of spiro 1,2,4-trioxanes. Wherein, Ar represents aryl groups such as phenyl, 4-biphenyl, 4-c

Orally active 1,2,4-trioxanes: Synthesis and antimalarial assessment of a new series of 9-functionalized 3-(1-arylvinyl)-1,2,5-trioxaspiro[5.5]undecanes against multi-drug-resistant Plasmodium yoelii nigeriensis in mice

Using easily accessible keto-trioxanes 7a-g as the starting materials, a series of new variously functionalized 1,2,4-trioxanes 10-36 have been prepared and evaluated for antimalarial activity against multi-drug-resistant Plasmodium yoelii nigeriensis in

AMINO-FUNCTIONALIZED 1,2,4-TRIOXANES USEFUL AS ANTIMALARIAL AGENTS AND PROCESS FOR PREPARATION THEREOF

The present invention relates to a novel series of antimalarial amino functionalized 1,2,4-trioxane analogues of formula 4 wherein Ar represents aryl groups such as phenyl, 4-biphenyl, 4-chlorophenyl, 4-methoxyphenyl, 4-methylphenyl and R represents pheny

AMINO-FUNCTIONALIZED 1,2,4-TRIOXANES USEFUL AS ANTI-MALARIAL AGENTS AND PROCESS FOR PREPARATION THEREOF

The present invention relates to a novel series of antimalarial amino functionalized 1,2,4-trioxane analogues of formula (4): wherein Ar represents aryl groups such as phenyl, 4-biphenyl, 4-chlorophenyl, 4-methoxyphenyl, 4-methylphenyl and R represents ph

Orally active amino functionalized antimalarial 1,2,4-trioxanes

Using readily available trioxanes 6a-b, a new series of amino functionalized 1,2,4-trioxanes 8a-e and 9a-e have been prepared and evaluated for antimalarial activity against multi-drug resistant Plasmodium yoelii in Swiss mice model. Several of these nove

6-hydroxymethyl-1,2,4-trioxanes and derivatives: An alternative 1,2,4-trioxane synthesis from β′γ′-unsaturated β-hydroxyhydroperoxides

Allylic hydroperoxides CH2:C(Ph)CH(OOH)CH2OX (X = H, CONHPh, Ac), from regiospecific photooxygenation of allylic alcohols CH3C(Ph):CHCH2OX, form hemiperoxyacetals with aldehydes or ketones which upon cyclisation with mercury(II) trifluoroacetate then reduction with sodium borohydride diastereoselectively afford 1,2,4-trioxanes with XOCH2 substituents at C-6.

Preparation of β-hydroxyhydroperoxides by photooxygenation of allylic alcohols and their elaboration into 1,2,4-trioxanes

Dye-sensitized photooxygenation of 3-aryl-2-butenols 2a-e furnishes 3-aryl-1-hydroxy-but-3-en-2-hydroperoxides 3a-e which condense with aldehydes and ketones to give active antimalarial 1,2,4-trioxanes.