132537-82-7

Basic information

• Product Name: Benzenepropanol, b-[(6-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-, (S)-
• CAS NO: 132537-82-7
• Molecular Formula: C20H18ClN5O
• Molecular Weight: 379.849
• Mol File: 132537-82-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenepropanol, b-[(6-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanol, b-[(6-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-, (S)-(132537-82-7)
• EPA Substance Registry System: Benzenepropanol, b-[(6-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-, (S)-(132537-82-7)

Safety Data

• Hazardous Substances Data: 132537-82-7(Hazardous Substances Data)

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 99971-84-3 4,6-dichloro-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine 

Downstream Products

• 133973-80-5 (S)-2,7-dihydro-7-phenyl-2-(phenylmethyl)-5-propoxy-3H-imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine 
• 133973-87-2 (S)-2,7-dihydro-7-phenyl-2-(phenylmethyl)-5-chloro-3H-imidazo<1,2-c>pyrazolo<4,3-e>pyrimidine 

Relevant articles and documents

Conformationally restrained, chiral (phenylisopropyl)amino-substituted pyrazolo[3,4-d]pyrimidines and purines with selectivity for adenosine A1 and A2 receptors

Two modes of tethering a chiral (phenylisopropyl)amino substituent in pyrazolo[3,4-d]pyrimidines and purines have been explored. One mode gave (S)- 2,7-dihydro-7-phenyl-2-(phenylmethyl)-5-propoxy-3H-imidazo[1,2-c]pyrazolo- [4,3-e]pyrimidine (12a) and its corresponding R-enantiomer 12b, which were selective for A2 and A1 adenosine receptors, respectively. The corresponding diimidazo[1,2-c:4',5'-e]pyrimidines 12e and 12f were analogously selective. This is the first example where a single chiral recognition unit provides enantiomers with opposite selectivities for adenosine receptors. The second mode gave (2S-trans)-2,7-dihydro-2-methyl- 3,7-diphenyl-5-propoxy-3H-imidazo[1,2-c]-pyrazolo[4,3-e]pyrimidine (12c) and its corresponding R-enantiomer 12d. Compounds 12c and 12d were significantly less potent than 12a and 12b at A1 receptors, and were nonselective.