132544-84-4Relevant academic research and scientific papers
Design and synthesis of new phthalazinone derivatives containing benzyl moiety with anticipated antitumor activity
Marzouk, Magda Ismail,Shaker, Soheir Ahmad,Hafiz, Aisha Ali Abdel,El-Baghdady, Khaled Zakaria
, p. 239 - 251 (2017/02/15)
The acetohydrazide derivative reacted with carbon electrophiles such as acid chlorides, acetylacetone, ethyl acetoacetate and aromatic aldehydes to give some interesting heterocyclic compounds. The hydrazide derivative reacted with acetophenone which in turn underwent Vielsmeier-Haack reaction. Also, the phthalazinethione has been synthesized and its behavior towards hydrazine hydrate, oxidizing agent and ethyl chloroacetate has been investigated. The newly synthesized compounds were characterized by spectroscopic data. The antimicrobial, the cytotoxic, and the antioxidant activities of some of the synthesized products were evaluated. Some of the tested compounds showed very strong cytotoxic activity with respect to the standard.
Synthesis and biological activity of some 4-benzyl-1(2H)-phthalazinone derivatives
El-Tamaty, El-Sayed H.,Abdel-Fattah, Mohy E.,El-Deen, Ibrahim M.
, p. 1067 - 1072 (2007/10/03)
4-Benzylphthalazin-1(2H)-one (2) has been prepared by treating benzalphthalide (1) with hydrazine. Alkylation of 2 with ethyl chloroacetate furnishes the ester 3, which on reaction with hydrazine affords hydrazide 4. The reactions of 4 with aldehydes, ketones, arylsulphonyl chlorides, phenylisocyanate, phenylisothiocyanate, benzoyl chloride, acetylacetone and carbon disulphide are studied. Cyclization of thiosemicarbazide (7b) with sodium hydroxide gives triazole derivative 17. The alkylation, Mannich and Michael reactions with triazole 17 are studied. The structures of the synthesized compounds have been established by their elemental analysis and spectral data. All the new compounds have been tested for their antibacterial and fungicidal activities and some of them have been found to be biologically active.
