132553-79-8

Upstream product

• 112547-04-3 (E)-N-[3-(1-Triphenylmethyl-1H-imidazol-4-yl)allyl]phthalimid 
• 76-83-5 trityl chloride 
• 3465-72-3 urocanic Acid 
• 138408-38-5 (E)-3-(1-Triphenylmethyl-1H-imidazol-4-yl)allylchlorid Hydrochlorid 
• 138408-37-4 1-(triphenylmethyl)-4-(3-hydroxyprop-1-enyl)imidazole 
• 138408-36-3 trans-1-trityl-4-imidazoleacrylic acid methyl ester 
• 54260-89-8 trans-4-imidazoleacrylic acid methyl ester hydrochloride 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 131120-95-1 N-<3-(1-trityl-1H-imidazol-4-yl)prop-2-enyl>-trichloroacetamide trans 

Downstream Products

• 144284-43-5 N-(3,3-Diphenyl-propyl)-N'-[(E)-3-(1H-imidazol-4-yl)-allyl]-guanidine; compound with picric acid 
• 144284-39-9 N-[(E)-3-(1H-Imidazol-4-yl)-allyl]-N'-[2-(pyridin-2-ylmethylsulfanyl)-ethyl]-guanidine; compound with picric acid 
• 144284-41-3 N-(2-Benzylsulfanyl-ethyl)-N'-[(E)-3-(1H-imidazol-4-yl)-allyl]-guanidine; compound with picric acid 
• 144153-39-9 N-Benzoyl-N'-(3,3-diphenyl-propyl)-N''-[(E)-3-(1-trityl-1H-imidazol-4-yl)-allyl]-guanidine 
• 144153-37-7 N-Benzoyl-N'-[2-(pyridin-2-ylmethylsulfanyl)-ethyl]-N''-[(E)-3-(1-trityl-1H-imidazol-4-yl)-allyl]-guanidine 
• 144153-38-8 N-Benzoyl-N'-(2-benzylsulfanyl-ethyl)-N''-[(E)-3-(1-trityl-1H-imidazol-4-yl)-allyl]-guanidine 
• 158229-43-7 3-(2-azido-1-trityl-1H-imidazol-4-yl)-N-trityl-prop-2-enamine 
• 158229-44-8 1-trityl-4-<3-(tritylamino)-prop-1-enyl>-1H-imidazol-2-amine 
• 144153-40-2 N-benzoyl-N'-<3-(1-triphenylmethyl-1H-imidazol-4-yl)-2-propen-1-yl>-O-phenylisourea 

Relevant academic research and scientific papers

Synthesis of 2-aminoimidazole marine metabolites: clathrodine and 3'-amino-1'--prop-2'-ene

The synthesis of 2-aminoimidazole marine metabolites has induced various studies on the reactivity of the imidazole nucleus, especially in positions 2 and 4(5); these studies were helpful to prepare naturally occuring clathrodine and 3'-amino-1'-2-aminoi

Synthesis of (Z)- and (E)-3-(1H-imidazol-4-yl)-2-propenamine and some 3-(1H-imidazol-4-yl)propanamines

3-(1H-Imidazol-4-yl)propanamine (6, homohistamine), an essential intermediate for the synthesis of potent impromidine-type histamine H2 receptor agonists, is efficiently prepared from trans-urocanic acid (1) by reduction of the methyl ester 2 and conversion to the saturated amide 4.Dehydration with thionyl chloride yields the nitrile 5 which is subsequently reduced to 6.Side-chain methylated 3-(1H-imidazol-4-yl)propanamines 12 are available from 1H-imidazole-4-carbaldehyde (7) and 1-(1H-imidazol-4-yl)ethanone (8), respectively, via unsaturated nitriles 10 and stepwise reduction.Cyclization of the appropiate 4-bromo-5-oxohexanenitriles 14α with formamidine in liquid ammonia and reduction of the obtained nitriles 15 furnishes ring-methylated amines 16. (E)-3-(1H-Imidazol-4-yl)-2-propenamine is obtained in six steps from the trans-ester 2 while (Z)-23 is accessible by treating 7 with triphenyl(2-phthalimidoethyl)phosphonium bromide (17) and final deprotection.These primary amines are valuable intermediates for the synthesis of impromidine analogues. Key Words: Homohistamine / Imidazole derivatives / 2-Propenamine derivatives / Impromidine