132557-22-3Relevant academic research and scientific papers
A novel one-pot, three-component access to hexahydropyrrolo[2,1-a] isoquinolines by an alkylation-dehydrohalogenation-1,3-dipolar cycloaddition sequence
Nyerges, Miklos,Somfai, Barbara,Toth, Judit,Toke, Laszlo,Dancso, Andras,Blasko, Gabor
, p. 2039 - 2045 (2005)
A simple one-pot process for the alkylation of isoquinolines followed by a dehydrohalogenation of the quaternary salts formed and by an in situ trapping of azomethine ylides with appropriate dipolarophiles is described. This method has successfully been a
STEREOCHEMICAL STUDY OF 1,3-DIPOLAR CYCLOADDITIONS OF AN ISOQUINOLINE-N-METHYLIDE WITH β-NITROSTYRENES
Tischer, Thomas,Toke, Laszlo,Toth, Gabor
, p. 171 - 172 (2007/10/02)
1,3-Dipolar cycloadditions of 3,4-dihydro-6,7-dimethoxyisoquinoline-N-methoxycarbonyl-methylide (1) with β-nitrostyrenes give kinetically controlled cycloadducts in a stereoselective pathway.By epimerization at C-10b an equilibrium of the products is established.The stereostructures of the products have been determined by 1H- and 13C-nmr spectroscopy.
