132559-91-2

Basic information

• Product Name: 4-Bromo-6-Methyl-2H-Pyran-2-One
• Synonyms: 4-Bromo-6-Methyl-2H-Pyran-2-One;2H-Pyran-2-one, 4-bromo-6-methyl-;4-bromo-6-methyl-2(2H)-pyranone;4-Bromo-6-Methyl-2H-Pyran-2-One(WXC01361)
• CAS NO: 132559-91-2
• Molecular Formula: C₆H₅BrO₂
• Molecular Weight: 189.0067
• Mol File: 132559-91-2.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-Bromo-6-Methyl-2H-Pyran-2-One(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-6-Methyl-2H-Pyran-2-One(132559-91-2)
• EPA Substance Registry System: 4-Bromo-6-Methyl-2H-Pyran-2-One(132559-91-2)

Safety Data

• Hazardous Substances Data: 132559-91-2(Hazardous Substances Data)

Upstream product

• 675-10-5 4-hydroxy-6-methyl-2-pyron 

Downstream Products

• 1334224-68-8 6-methyl-4-[4-(trifluoromethoxy)phenyl]-2(2H)-pyranone 
• 1323128-31-9 4-(4-tert-butylphenyl)-6-methyl-2H-pyran-2-one 
• 1421194-13-9 4-(3-ethoxycarbonylphenyl)-6-methyl-2-pyranone 
• 1357190-65-8 C₁₇H₁₈O₃ 
• 1357190-72-7 C₁₂H₁₁NO₂ 
• 1357190-62-5 C₁₃H₁₆O₃ 
• 1357190-71-6 C₁₂H₁₁NO₂ 
• 1357190-56-7 C₁₄H₁₂O₄ 
• 104750-21-2 4-Benzoyl-6-methyl-pyran-2-one 
• 1357190-57-8 C₁₄H₁₁ClO₃ 
• 1357190-73-8 C₁₂H₁₀O₃ 
• 1357190-55-6 C₁₃H₉BrO₃ 
• 1315330-27-8 C₂₆H₂₈O₄ 
• 1097663-57-4 4-(4-methoxyphenylethynyl)-6-methyl-2-pyrone 

Relevant articles and documents

Bioactive 4-substituted-6-methyl-2-pyrones with promising cytotoxicity against A2780 and K562 cell lines.

Bioactive synthetic 4-substituted-6-methyl-2-pyrones are reported. Various 4-substitutents have been incorporated using Pd-catalysed carbon-carbon bond coupling procedures. Preliminary screening of the 2-pyrones against human ovarian carcinoma (A2780) and

PI3K INHIBITORS AND USES THEREOF

The development of a new, targeted drug delivery paradigm coupled to improved PI3K inhibitors (e.g., PI3Kα inhibitors) represents a significant advance in cancer therapy. Provided herein are compounds, such as compounds of Formula (I) and (II), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The compounds provided herein are PI3K (e.g., PI3Kα) inhibitors and are therefore useful for the treatment and/or prevention of various diseases (e.g., proliferative diseases such as cancer). Also provided herein are nanoparticles and nanogels (e.g., P-selectin targeting nanoparticles) comprising PI3K inhibitors, such a compound described herein. In certain embodiments, a nanoparticle or nanogel described herein encapsulates a compound described herein for targeting delivery to cancer cells or tumors.

Synthesis of trifluoromethylthiolated and trifluoromethylselenolated pyrones

Trifluoromethylthiolation and trifluoromethylselenolation of 3- or 4-iodo(bromo)-2-pyrones with (bpy)CuSCF3 and [(bpy)CuSeCF3]2 provide a convenient method for the synthesis of trifluoromethylthio(seleno)lated 4-alkoxy-, aryloxy-, and benzyloxy-2-pyrones in high yields.

Intramolecular Direct Arylation of 3-Halo-2-pyrones and 2-Coumarins

Direct arylation represents a favorable alternative to traditional cross-coupling and has found widespread use with simple aryls and robust heterocycles. Herein a direct arylation protocol has been optimized and applied to 2-pyrones, which are delicate an