132559-91-2Relevant articles and documents
Bioactive 4-substituted-6-methyl-2-pyrones with promising cytotoxicity against A2780 and K562 cell lines.
Marrison, Lester R,Dickinson, Julia M,Fairlamb, Ian J S
, p. 3509 - 3513 (2002)
Bioactive synthetic 4-substituted-6-methyl-2-pyrones are reported. Various 4-substitutents have been incorporated using Pd-catalysed carbon-carbon bond coupling procedures. Preliminary screening of the 2-pyrones against human ovarian carcinoma (A2780) and
PI3K INHIBITORS AND USES THEREOF
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Paragraph 00423-00424, (2020/05/15)
The development of a new, targeted drug delivery paradigm coupled to improved PI3K inhibitors (e.g., PI3Kα inhibitors) represents a significant advance in cancer therapy. Provided herein are compounds, such as compounds of Formula (I) and (II), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The compounds provided herein are PI3K (e.g., PI3Kα) inhibitors and are therefore useful for the treatment and/or prevention of various diseases (e.g., proliferative diseases such as cancer). Also provided herein are nanoparticles and nanogels (e.g., P-selectin targeting nanoparticles) comprising PI3K inhibitors, such a compound described herein. In certain embodiments, a nanoparticle or nanogel described herein encapsulates a compound described herein for targeting delivery to cancer cells or tumors.
Synthesis of trifluoromethylthiolated and trifluoromethylselenolated pyrones
Zhang, Yunxiao,Yang, Ding-Yah,Weng, Zhiqiang
supporting information, p. 3853 - 3859 (2017/06/13)
Trifluoromethylthiolation and trifluoromethylselenolation of 3- or 4-iodo(bromo)-2-pyrones with (bpy)CuSCF3 and [(bpy)CuSeCF3]2 provide a convenient method for the synthesis of trifluoromethylthio(seleno)lated 4-alkoxy-, aryloxy-, and benzyloxy-2-pyrones in high yields.
Intramolecular Direct Arylation of 3-Halo-2-pyrones and 2-Coumarins
Nolan, Marie-T.,Pardo, Leticia M.,Prendergast, Aisling M.,McGlacken, Gerard P.
, p. 10904 - 10913 (2015/11/18)
Direct arylation represents a favorable alternative to traditional cross-coupling and has found widespread use with simple aryls and robust heterocycles. Herein a direct arylation protocol has been optimized and applied to 2-pyrones, which are delicate an