13256-22-9

Basic information

• Product Name: N-NITROSOSARCOSINE
• Synonyms: nitrososarkosin;n-methyl-n-(carboxymethyl)nitrosamine;n-methyl-n-nitroso-glycin;n-methyl-n-nitrosoglycine;n-nitrosomethylglycine;n-nitroso-sarcosin;NITROSOSARCOSINE;2-(MethylnitrosoaMino)acetic Acid
• CAS NO: 13256-22-9
• Molecular Formula: C₃H₆N₂O₃
• Molecular Weight: 118.09134
• Product Categories: Detergents;Mutagenesis Research Chemicals;Aliphatics
• Mol File: 13256-22-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 66-67°C
• Boiling Point: 220.6°C (rough estimate)
• Flash Point: 167.4°C
• Appearance: /
• Density: 1.5267 (rough estimate)
• Vapor Pressure: 6.18E-06mmHg at 25°C
• Refractive Index: 1.4715 (estimate)
• Storage Temp.: -20°C Freezer
• PKA: 3.40±0.10(Predicted)
• CAS DataBase Reference: N-NITROSOSARCOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-NITROSOSARCOSINE(13256-22-9)
• EPA Substance Registry System: N-NITROSOSARCOSINE(13256-22-9)

Safety Data

• RIDADR: 2811
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 13256-22-9(Hazardous Substances Data)

Usage

Chemical Properties

Pale-Yellow Crystalline Solid

Uses

Different sources of media describe the Uses of 13256-22-9 differently. You can refer to the following data:
1. A carcinogenic compound
2. A carcinogenic compound.

Definition

ChEBI: A nitrosamine that is sarcosine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group.

Safety Profile

Confirmed carcinogen with experimental tumorigenic data. Mildly toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.See also N-NITROSO COMPOUNDS.

Carcinogenicity

N-Nitrososarcosine is reasonably anticipated to b e a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

InChI:InChI=1/C3H6N2O3/c1-5(4-8)2-3(6)7/h2H2,1H3,(H,6,7)

Upstream product

• 107-97-1 sarcosine 
• 80-11-5 N-methyl-N-nitrosotoluene-p-sulfonamide 
• 1118-68-9 dimethylaminoacetic acid 
• 67809-83-0 S-nitroso-N-acetylpenicillamine 
• 10242-53-2 2--acetamid 

Downstream Products

• 51938-19-3 C₄H₈N₂O₃ 
• 53261-86-2 C₁₃H₁₆N₄O₆ 
• 6939-12-4 N-methylsydnone 
• 25044-54-6 Nitroso-sarkosin-2,4,6-trimethylbenzylester; NO-Sar-OTMB 
• 25044-59-1 N-Nitroso-sarkosin-<4-nitro-phenylester> 
• 20661-60-3 N-methyl-N-nitroglycine 
• 107-97-1 sarcosine 
• 25044-53-5 N-Nitroso-sarkosin-<4-brom-phenacylester> 

Relevant articles and documents

NITROSATION REAGENTS AND METHODS

Provided are compounds that can find use as nitrosation reagents. Provided are nitrosation methods that include reacting a substrate with one of the provided nitrosation reagents and thereby generating a nitrosation product. Provided are kits including a nitrosation reagent. Provided are compositions wherein the nitrosation reagent is enriched in the 15N isotope.

Bioorthogonal Click and Release Reaction of Iminosydnones with Cycloalkynes

We report the discovery of a new bioorthogonal click-and-release reaction involving iminosydnones and strained alkynes. This transformation leads to two products resulting from the ligation and fragmentation of iminosydnones under physiological conditions. Optimized iminosydnones were successfully used to design innovative cleavable linkers for protein modification, thus opening up new areas in the fields of drug release and target-fishing applications. This click-and-release technology offers the possibility of exchanging tags on proteins for functionalized cyclooctynes under mild and bioorthogonal conditions.

4-Halogeno-sydnones for fast strain promoted cycloaddition with bicyclo-[6.1.0]-nonyne

New sydnone derivatives have been synthesized and screened for their capacity to undergo fast copper-free cycloaddition reaction with bicyclo-[6.1.0]-nonyne. The influences of substitution in positions N-3 and C-4 of sydnones have been particularly studied leading to the identification of highly reactive partners for bio-orthogonal ligation reactions.