13256-77-4Relevant articles and documents
“Urea to Urea” Approach: Access to Unsymmetrical Ureas Bearing Pyridyl Substituents
Kasatkina, Svetlana O.,Geyl, Kirill K.,Baykov, Sergey V.,Novikov, Mikhail S.,Boyarskiy, Vadim P.
supporting information, p. 1295 - 1304 (2022/03/15)
A protocol for the synthesis of unsymmetrical ureas substituted by pyridyl/quinolinyl moiety has been developed. This method concluded in metal- and base-free reamination of N,N-dimethyl-N‘-hetaryl ureas with a wide range of aryl and alkyl amines. The isolated yields vary from 40 to 96% depending on the nucleophilicity of the amines. The scope of this method includes more than 50 examples. The reaction is not hindered by either donor or acceptor groups as well as diverse functionalities. The synthesis can be easily scaled to gram quantities. Theoretical calculations supported by experimental data allowed us to propose a plausible mechanism for the process. This reaction takes place through the intermediate formation of hetaryl isocyanate. (Figure presented.).
Substituent effect of N-aryl-N′-pyridyl ureas as thermal latent initiators on ring-opening polymerization of epoxide
Makiuchi, Naoyuki,Sudo, Atsushi,Endo, Takeshi
, p. 2569 - 2574 (2015/10/12)
A series of N-aryl-N′-pyridyl ureas were synthesized by the reactions of 4-aminopyridine (4AP) with the corresponding isocyanates such as phenyl isocyanate, 4-methylphenyl isocyanate, 4-methoxyphenyl isocyanate, 4-chlorophenyl isocyanate, 4-(trifluorometh
Heteroacyl Azides as Acylating Agents for Aromatic or Heteroatomic Amines (1)
Stanovnik, B.,Tisler, M.,Golob, V.,Hvala, I.,Nikolic, O.
, p. 733 - 736 (2007/10/02)
The possibility of formation of substituted heterocyclic amides from heteroacyl azides and aromatic or heteroatomic amines was investigated.Although acylation proceeded in some cases under mild reaction conditions, formation of N,N'-disubstituted ureas was the main process at elevated temperatures.
