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132567-75-0

2-pentadeuteriophenyl-quinoline-4-carboxylic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 132567-75-0 Structure

  • Basic information

    1. Product Name: 2-pentadeuteriophenyl-quinoline-4-carboxylic acid
    2. Synonyms: 2-pentadeuteriophenyl-quinoline-4-carboxylic acid
    3. CAS NO:132567-75-0
    4. Molecular Formula:
    5. Molecular Weight: 254.229
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 132567-75-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-pentadeuteriophenyl-quinoline-4-carboxylic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-pentadeuteriophenyl-quinoline-4-carboxylic acid(132567-75-0)
    11. EPA Substance Registry System: 2-pentadeuteriophenyl-quinoline-4-carboxylic acid(132567-75-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 132567-75-0(Hazardous Substances Data)

132567-75-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 132567-75-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,5,6 and 7 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 132567-75:
(8*1)+(7*3)+(6*2)+(5*5)+(4*6)+(3*7)+(2*7)+(1*5)=130
130 % 10 = 0
So 132567-75-0 is a valid CAS Registry Number.

132567-75-0Downstream Products

132567-75-0Relevant articles and documents

Development of broad-spectrum enterovirus antivirals based on quinoline scaffold

Musharrafieh, Rami,Kitamura, Naoya,Hu, Yanmei,Wang, Jun

, (2020)

Non-polio enteroviruses such as enterovirus A71 (EV-A71), EV-D68, and coxsackievirus B3 (CVB3) are significant human pathogens with disease manifestations ranging from mild flu-like symptoms to more severe encephalitis, myocarditis, acute flaccid paralysis/myelitis, and even death. There is currently no effective antivirals to prevent or treat non-polio enterovirus infection. In this study, we report our progress in developing potent and broad-spectrum antivirals against these non-polio enteroviruses. Starting from our previously developed lead compounds that had potent antiviral activity against EV-D68, we synthesized 43 analogs and profiled their broad-spectrum antiviral activity against additional EV-D68, EV-A71, and CVB3 viruses. Promising candidates were also selected for mouse microsomal stability test to prioritize lead compounds for future in vivo mouse model studies. Collectively, this multi-parameter optimization process revealed a promising lead compound 6aw that showed single-digit to submicromolar EC50 values against two EV-D68 strains (US/KY and US/MO), two EV-A71 strains (Tainan and US/AK), and one CVB3 strain, with a high selectivity index. Encouragingly, 6aw was stable in mouse microsomes with a half-life of 114.7 min. Overall, 6aw represents one of the most potent broad-spectrum antiviral against non-polio enteroviruses, rendering it a promising lead candidate for non-polio enteroviruses with translational potential.

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