132567-75-0

Basic information

• Product Name: 2-pentadeuteriophenyl-quinoline-4-carboxylic acid
• Synonyms: 2-pentadeuteriophenyl-quinoline-4-carboxylic acid
• CAS NO: 132567-75-0
• Molecular Weight: 254.229
• Mol File: 132567-75-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-pentadeuteriophenyl-quinoline-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-pentadeuteriophenyl-quinoline-4-carboxylic acid(132567-75-0)
• EPA Substance Registry System: 2-pentadeuteriophenyl-quinoline-4-carboxylic acid(132567-75-0)

Safety Data

• Hazardous Substances Data: 132567-75-0(Hazardous Substances Data)

Upstream product

• 5467-57-2 2-chloroquinoline-4-carboxylic acid 
• 215527-70-1 2,3,4,5,6-pentadeuteriumbenzeneboronic acid 
• 28077-64-7 acetophenone-d5 
• 91-56-5 indole-2,3-dione 

Relevant articles and documents

Development of broad-spectrum enterovirus antivirals based on quinoline scaffold

Non-polio enteroviruses such as enterovirus A71 (EV-A71), EV-D68, and coxsackievirus B3 (CVB3) are significant human pathogens with disease manifestations ranging from mild flu-like symptoms to more severe encephalitis, myocarditis, acute flaccid paralysis/myelitis, and even death. There is currently no effective antivirals to prevent or treat non-polio enterovirus infection. In this study, we report our progress in developing potent and broad-spectrum antivirals against these non-polio enteroviruses. Starting from our previously developed lead compounds that had potent antiviral activity against EV-D68, we synthesized 43 analogs and profiled their broad-spectrum antiviral activity against additional EV-D68, EV-A71, and CVB3 viruses. Promising candidates were also selected for mouse microsomal stability test to prioritize lead compounds for future in vivo mouse model studies. Collectively, this multi-parameter optimization process revealed a promising lead compound 6aw that showed single-digit to submicromolar EC50 values against two EV-D68 strains (US/KY and US/MO), two EV-A71 strains (Tainan and US/AK), and one CVB3 strain, with a high selectivity index. Encouragingly, 6aw was stable in mouse microsomes with a half-life of 114.7 min. Overall, 6aw represents one of the most potent broad-spectrum antiviral against non-polio enteroviruses, rendering it a promising lead candidate for non-polio enteroviruses with translational potential.