1325673-25-3Relevant academic research and scientific papers
Discovery and synthesis of a new class of opioid ligand having a 3-azabicyclo[3.1.0]hexane core. An example of a 'magic methyl' giving a 35-fold improvement in binding
Lunn, Graham,Banks, Bernard J.,Crook, Robert,Feeder, Neil,Pettman, Alan,Sabnis, Yogesh
, p. 4608 - 4611 (2011)
In looking for a novel achiral μ opioid receptor antagonist for the treatment of pruritus, we designed and synthesised azabicyclo[3.1.0]hexane compounds as a new class of opioid ligand. During optimisation, an addition of a single methyl resulted in a 35-
