1325682-71-0

Basic information

• Product Name: 1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid 2,2,2-trifluoroethyl ester
• Synonyms: 1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid 2,2,2-trifluoroethyl ester
• CAS NO: 1325682-71-0
• Molecular Weight: 363.296
• Mol File: 1325682-71-0.mol

Chemical Properties

• CAS DataBase Reference: 1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid 2,2,2-trifluoroethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid 2,2,2-trifluoroethyl ester(1325682-71-0)
• EPA Substance Registry System: 1-(3-aminobenzoyl)-1H-indazole-3-carboxylic acid 2,2,2-trifluoroethyl ester(1325682-71-0)

Safety Data

• Hazardous Substances Data: 1325682-71-0(Hazardous Substances Data)

Upstream product

• 1325682-89-0 1-(3-tert-butoxycarbonylaminobenzoyl)-1H-indazole-3-carboxylic acid 2,2,2-trifluoroethyl ester 

Relevant articles and documents

Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase

Human neutrophil elastase (HNE) plays an important role in tumour invasion and inflammation. A series of N-benzoylindazoles was synthesized and evaluated for their ability to inhibit HNE. We found that this scaffold is appropriate for HNE inhibitors and that the benzoyl fragment at position 1 is essential for activity. The most active compounds inhibited HNE activity with IC50 values in the submicromolar range. Furthermore, docking studies indicated that the geometry of an inhibitor within the binding site and energetics of Michaelis complex formation were key factors influencing the inhibitor's biological activity. Thus, N-benzoylindazole derivatives and their analogs represent novel structural templates that can be utilized for further development of efficacious HNE inhibitors.