1325694-78-7Relevant articles and documents
Synthesis of an aryloxy oxo pyrimidinone library that displays ALK-selective inhibition
Slavish, P. Jake,Price, Jeanine E.,Jiang, Qin,Cui, Xiaoli,Morris, Stephan W.,Webb, Thomas R.
supporting information; experimental part, p. 4592 - 4596 (2011/09/15)
We report the synthesis of a pyrimidinone library that targets anaplastic lymphoma kinase (ALK), an oncogenic receptor tyrosine kinase. This library was generated in three steps from a versatile commercially available starting material. Some compounds wit