132616-92-3Relevant academic research and scientific papers
KAPPA OPIOID RECEPTOR BINDING LIGANDS
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Paragraph 0208, (2013/06/28)
Kappa opioid recep-tor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor, such as heroin or cocaine addictions.
KAPPA OPIOID RECEPTOR BINDING LIGANDS
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Page/Page column 19, (2011/08/08)
Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid
Chiral azo compounds: Enantioselective synthesis and transformations into β-amino alcohols and α-amino acids with a quaternary stereocenter
Dietz, Friedrich R.,Prechter, Agnes,Gr?ger, Harald,Heinrich, Markus R.
, p. 655 - 657 (2011/03/21)
Taking advantage of radical carboaminations producing azo compounds, a new chemo-enzymatic approach to enantiomerically enriched azo alcohols, β-amino alcohols and non-natural (aromatic) amino acids with a quaternary stereocenter is reported.
KAPPA OPIOID RECEPTOR LIGANDS
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Page/Page column 6, (2009/10/30)
Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid
Synthesis and in vitro opioid receptor functional antagonism of methyl-substituted analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3- hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3, 4-tetrahydro-3-isoquinolinecarboxamide (JDTic
Cueva, Juan Pablo,Cai, Tingwei Bill,Mascarella, S. Wayne,Thomas, James B.,Navarro, Herńan A.,Carroll, F. Ivy
experimental part, p. 7463 - 7472 (2010/06/19)
In previous structure-activity relationship (SAR) studies, (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1- piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3- isoquinolinecarboxamide (JDTic, 3) was identified as the first pote
Synthesis of Optically Pure α-Alkylated α-Amino Acids and a Single-Step Method for Enatiomeric Excess Determination
Kruizinga, Wim H.,Bolster, John,Kellogg, Richard M.,Kamphuis, Johan,Boesten, Wilhelmus H. J.,et al.
, p. 1826 - 1827 (2007/10/02)
A method for the enzymatic resolution of the amides of some racemic α-alkylated amino acids is described as well as a method involving derivatization with (S)-2-chloropropionyl chloride followed by 1H NMR analysis to establish the enantiomeric excesses of the free amino acids.
