132619-21-7

Basic information

• Product Name: (Z)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone
• Synonyms: (Z)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone
• CAS NO: 132619-21-7
• Molecular Weight: 668.931
• Mol File: 132619-21-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (Z)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone(132619-21-7)
• EPA Substance Registry System: (Z)-1-<2-deoxy-2--3,5-O-<1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl>-β-D-erythro-pentofuranosyl>-4-ethoxy-2(1H)-pyrimidinone(132619-21-7)

Safety Data

• Hazardous Substances Data: 132619-21-7(Hazardous Substances Data)

Upstream product

• 20808-12-2 fluoromethyl phenyl sulfone 
• 113648-22-9 4-ethoxy-1-<3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-erythro-2-pentulofuranosyl>-2(1H)-pyrimidinone 

Downstream Products

• 130306-02-4 (E)-2'-deoxy-2'-(fluoromethylene)cytidine 

Relevant articles and documents

Treatment of carcinoma by administration of 2'-halomethylidenyl-2'-deoxynucleosides

This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease stat

Stereospecific synthesis of 1-fluoro olefins via (fluoro-vinyl)stannanes and an unequivocal NMR method for the assignment of fluoro olefin geometry

(E)- and (Z)-Fluorovinyl sulfones (II) form (fluorovinyl)stannanes (III) on treatment with two equivalents of tributyltin hydride and a catalytic amount of AIBN; the free radical catalyzed reaction proceeds with retention of configuration for 2,2-disubstituted fluorovinyl sulfones (IIa and IIb). Conversion of III to 1-fluoro olefins (IV) is a stereospecific reaction and provides a general method to (E) and (Z) fluoro olefins. The utility of this method is exemplified by the synthesis of the deutero fluoro olefins 27, nucleosides 32 and 34, and the amino acids 43 and 47. Proton observe, 19F irradiated (1H-{19F}) NOE difference spectroscopy was used for the first time as an unequivocal method for the assignment of olefin geometry for fluorovinyl sulfones, (fluorovinyl)stannanes and fluoro olefins.

Stereospecific method to E and Z terminal fluoro olefins and its application to the synthesis of 2'-deoxy-2'-fluoromethylene nucleosides as potential inhibitors of ribonucleoside diphosphate reductase

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