13262-38-9

Usage

Physical State

White crystalline solid

Solubility

Soluble in water

Industrial and Scientific Applications

Used as a building block in organic synthesis for the production of pharmaceuticals, agrochemicals, and other specialty chemicals; used as a reagent in the synthesis of pyridine-containing compounds and in the preparation of heterocyclic compounds; studied for its potential as a corrosion inhibitor and as a component in polymeric materials.

Upstream product

• 125583-33-7 N-monochloroisonicotinamide 
• 504-24-5 4-aminopyridine 
• 917-61-3 sodium isocyanate 

Downstream Products

• 153539-26-5 4-(pyridin-4-yl)semicarbazide 
• 1026427-60-0 (E)-1-benzylidene-4-(pyridin-4-yl)semicarbazide 
• 1450600-77-7 (E)-1-(2-hydroxybenzylidene)-4-(pyridin-4-yl)semicarbazide 
• 1450600-78-8 (E)-1-(2,4-dihydroxybenzylidene)-4-(pyridin-4-yl)semicarbazide 
• 1450600-79-9 (E)-1-(4-methoxybenzylidene)-4-(pyridin-4-yl)semicarbazide 
• 1450600-80-2 (E)-1-(3,4-dimethoxybenzylidene)-4-(pyridin-4-yl)semicarbazide 
• 1450600-81-3 (E)-1-(4-hydroxy-3-methoxybenzylidene)-4-(pyridin-4-yl)semicarbazide 
• 1450600-82-4 1-(diphenylmethylene)-4-(pyridin-4-yl)semicarbazide 
• 1450600-83-5 (E)-1-(1-(4-hydroxyphenyl)ethylidene)-4-(pyridin-4-yl)semicarbazide 
• 125583-32-6 (1-methylpyridinium-4-)-urea iodide 

Relevant academic research and scientific papers

DIAZABICYCLOOCTANE DERIVATIVES COMPRISING A QUATERNERY AMMONIUM GROUP FOR USE AS ANTIBACTERIAL AGENTS

Compounds of Formula (I), pharmaceutical compositions comprising these compounds and their use in treating bacterial infection is disclosed.

Synthesis, evaluation and molecular dynamics study of some new 4-aminopyridine semicarbazones as an antiamnesic and cognition enhancing agents

Some new semicarbazones of 4-aminopyridine were synthesized and evaluated for antiamnesic, cognition enhancing and anticholinesterase activities. The results illustrated a significant cognition enhancing effect on elevated plus maze model with a significant reversal of scopolamine-induced amnesia. A significant inhibition in acetycholinesterase (AChE) activity by all the synthesized compounds in specific brain regions that is, prefrontal cortex, hippocampus and hypothalamus was observed. Compound 4APi exhibited significant antiamnesic and cognition enhancing activity which was comparable with standard drug donepezil. Its enzyme kinetic study revealed a non-competitive inhibition of AChE and a competitive inhibition of butyrylcholinesterase (BChE). Docking studies predicted the binding modes of these compounds in AChE active site, which were further processed for molecular dynamics simulation for calculating binding free energies using Molecular Mechanics-Generalized Born Surface Area (MM/GBSA). All the computational study confirmed their consensual interaction with AChE justifying the experimental outcome.