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Biphenyl-4-ylurea, also known as diphenyl-4-ylurea, is a chemical compound that consists of a urea molecule attached to a biphenyl group. It is recognized for its diverse range of biological activities, such as anti-inflammatory, anti-cancer, and antiviral properties. biphenyl-4-ylurea's structure and functional groups contribute to its versatility in the development of new chemical compounds with potential therapeutic applications, making it a valuable building block in organic synthesis and pharmaceutical research.

13262-48-1

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13262-48-1 Usage

Uses

Used in Pharmaceutical Research:
Biphenyl-4-ylurea is utilized as a building block in the development of pharmaceutical drugs due to its diverse biological activities and structural versatility. It aids in the creation of new chemical compounds with potential therapeutic applications.
Used in Agrochemical Development:
biphenyl-4-ylurea also serves as a building block in the development of agrochemicals, where its biological activities can be harnessed for applications in agriculture to improve crop protection and yield.
Used in Organic Synthesis:
Biphenyl-4-ylurea is employed as a key component in organic synthesis, where its unique structure allows for the formation of various complex organic molecules for a wide range of applications in the chemical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 13262-48-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,2,6 and 2 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 13262-48:
(7*1)+(6*3)+(5*2)+(4*6)+(3*2)+(2*4)+(1*8)=81
81 % 10 = 1
So 13262-48-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H12N2O/c14-13(16)15-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,(H3,14,15,16)

13262-48-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-phenylphenyl)urea

1.2 Other means of identification

Product number -
Other names amino-N-(4-phenylphenyl)amide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13262-48-1 SDS

13262-48-1Relevant academic research and scientific papers

Novel ATP-competitive kinesin spindle protein inhibitors

Parrish, Cynthia A.,Adams, Nicholas D.,Auger, Kurt R.,Burgess, Joelle L.,Carson, Jeffrey D.,Chaudhari, Amita M.,Copeland, Robert A.,Diamond, Melody A.,Donatelli, Carla A.,Duffy, Kevin J.,Faucette, Leo F.,Finer, Jeffrey T.,Huffman, William F.,Hugger, Erin D.,Jackson, Jeffrey R.,Knight, Steven D.,Luo, Lusong,Moore, Michael L.,Newlander, Ken A.,Ridgers, Lance H.,Sakowicz, Roman,Shaw, Antony N.,Sung, Chiu-Mei M.,Sutton, David,Wood, Kenneth W.,Zhang, Shu-Yun,Zimmerman, Michael N.,Dhanak, Dashyant

, p. 4939 - 4952 (2008/03/11)

Kinesin spindle protein (KSP), an ATPase responsible for spindle pole separation during mitosis that is present only in proliferating cells, has become a novel and attractive anticancer target with potential for reduced side effects compared to currently available therapies. We report herein the discovery of the first known ATP-competitive inhibitors of KSP, which display a unique activity profile as compared to the known loop 5 (L5) allosteric KSP inhibitors that are currently under clinical evaluation. Optimization of this series led to the identification of biphenyl sulfamide 20, a potent KSP inhibitor with in vitro antiproliferative activity against human cells with either wild-type KSP (HCT116) or mutant KSP (HCT116 D 130V). In a murine xenograft model with HCT116 D130V tumors, 20 showed significant antitumor activity following intraperitoneal dosing, providing in vivo proof-of-principle of the efficacy of an ATP-competitive KSP inhibitor versus tumors that are resistant to the other known KSP inhibitors.

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