132622-98-1

Basic information

• Product Name: (2R,4R)-1-BOC-4-AMINO-PYRROLIDINE-2-CARBOXYLIC ACID
• Synonyms: (2R,4R)-1-BOC-4-AMINO-PYRROLIDINE-2-CARBOXYLIC ACID;1-N-BOC-4(R)-AMINO-PYRROLIDINE-2(R)-CARBOXYLIC ACID;(2R,4R)-4-Amino-1,2-Pyrrolidinedicarboxylicacid 1-(1,1-dimethylethyl) ester;(2R-cis)-4-Amino-1,2-Pyrrolidinedicarboxylicacid 1-(1,1-dimethylethyl) ester;(2R,4R)-4-Amino-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester;N-boc-cis-4-AMino-D-Proline;(2R,4R)-4-amino-1-Boc-pyrrolidine-2-carboxylic acid;(2R,4R)
• CAS NO: 132622-98-1
• Molecular Formula: C₁₀H₁₈N₂O₄
• Molecular Weight: 230.26092
• Mol File: 132622-98-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 263-264℃
• Boiling Point: 371.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.232
• Storage Temp.: 2-8°C
• PKA: 3.65±0.20(Predicted)
• CAS DataBase Reference: (2R,4R)-1-BOC-4-AMINO-PYRROLIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4R)-1-BOC-4-AMINO-PYRROLIDINE-2-CARBOXYLIC ACID(132622-98-1)
• EPA Substance Registry System: (2R,4R)-1-BOC-4-AMINO-PYRROLIDINE-2-CARBOXYLIC ACID(132622-98-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 132622-98-1(Hazardous Substances Data)

Usage

General Description

(2R,4R)-1-BOC-4-AMINO-PYRROLIDINE-2-CARBOXYLIC ACID is a chemical compound with the molecular formula C11H20N2O4. It is a derivative of pyrrolidine and belongs to the class of amino acids. The compound contains a BOC (tert-butyloxycarbonyl) protecting group, which is commonly used in organic synthesis to temporarily protect certain functional groups during chemical reactions. (2R,4R)-1-BOC-4-AMINO-PYRROLIDINE-2-CARBOXYLIC ACID is used in the synthesis of various pharmaceuticals and organic compounds due to its versatile reactivity and stability. It is important in the development of new drugs and in the field of organic chemistry.

Upstream product

• 481704-22-7 (2R,4S)-2-benzyl 1-tert-butyl 4-hydroxypyrrolidine-1,2-dicarboxylate 
• 147266-92-0 (2R,4S )-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 132622-92-5 2-benzyl 1-(tert-butyl) (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate 
• 132622-89-0 benzyl (4R)-4-hydroxy-D-prolinate 
• 132622-93-6 (4S)-1-(tert-butoxycarbonyl)-4-bromo-D-proline benzyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 132622-97-0 2-benzyl 1-(tert-butyl) (2R,4R)-4-azidopyrrolidine-1,2-dicarboxylate 

Downstream Products

• 1018332-24-5 (2R,4R)-1-(tert-butoxycarbonyl)-4-N-(9-fluorenylmethoxycarbonyl)aminoproline 
• 132622-99-2 (4R)-1-(tert-butoxycarbonyl)-4-<<<(p-toluenesulfonyl)imino>aminomethyl>amino>-D-proline 

Relevant articles and documents

INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF

Provided herein are compounds that inhibit pKal, a serine protease whose activity is responsible for proteolytically cleaving kininogen and generating the potent vasodilator and pro-inflammatory peptide bradykinin, which can lead to painful and debilitating inflammatory attacks (e.g., edema). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating pKal-related diseases and disorders (e.g., edema) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Chimeric amino acid analogues

A chimeric amino acid analogue is provided suitable for incorporating into peptides which compound is represented by Formula 1: STR1 where P1 is preferably an amine protecting agent, and P2 and P3 are preferably amine or guanidine protecting agents. X can be OH, halide, or preferably an activating group suitable for conjugating the compound of Formula 1 to a peptide by conventional means, and m and n are 0-1 and 0-2 respectively. Peptides containing the chimeric amino acid analog are provided and include a platelet-aggregation inhibitor represented by where Aaa1 is Gly or H, Cpdl is the compound of Formula 1 which has been deprotected and Aaa2 is a hydrophobic amino acid preferably Val.