1326240-46-3

Upstream product

• 111609-57-5 1-(4-Chloro-phenyl)-3,4-dihydro-pyrrolo[1,2-a]pyrazine 
• 29709-35-1 1-(2-aminoethyl)pyrrole 
• 104-88-1 4-chlorobenzaldehyde 

Relevant academic research and scientific papers

Method for synthesizing chiral amine by asymmetric hydrogenation of dihydropyrrole/indol[1,2-a]pyrazine

The invention provides a method for synthesizing a chiral amine, which is prepared by catalytic asymmetric hydrogenation of dihydropyrrole/indol[1,2-a]pyrazine. A catalyst is a complex of an iridium metal precursor and a chiral bisphosphine ligand. The mo

Direct synthesis of chiral 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazines via a catalytic asymmetric intramolecular aza-Friedel-Crafts reaction

The direct asymmetric intramolecular aza-Friedel-Crafts reaction of N-aminoethylpyrroles with aldehydes catalyzed by a chiral phosphoric acid represents the first efficient method for the preparation of medicinally interesting chiral 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazines with high yields and high enantioselectivities. This strategy has been shown to be quite general toward various aldehydes and pyrrole derivatives.