1326317-17-2

Upstream product

• 1360441-86-6 methyl 2-(benzyloxycarbonylamino)-3-(3,4-dimethoxyphenyl)acrylate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 56771-16-5 2-amino-3-(3,4-dimethoxybenz-1-yl)propanoic acid methyl ester 
• 10538-49-5 3-(2,5-dimethoxyphenyl)propanoic acid 
• 88932-16-5 1,2,3,4-tetrahydro-6,7-dimethoxy-3-Isoquinolinecarboxylic acid methyl ester 
• 1326317-10-5 methyl 2-(tert-butoxycarbonylamino)-3-(3,4-dimethoxyphenyl)acrylate 

Downstream Products

• 1326317-23-0 2-(3-(2,5-dihydroxyphenyl)propanoyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Electronically rich N-substituted tetrahydroisoquinoline 3-carboxylic acid esters: Concise synthesis and conformational studies

Recent work in our laboratory has shown that the highly substituted, electronically rich 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQ3CA) scaffold is a key building block for a novel class of promising anticoagulants.10 The synthesis

Designing nonsaccharide, allosteric activators of antithrombin for accelerated inhibition of factor Xa

Antithrombin is a key regulator of coagulation and prime target of heparins, clinically used anticoagulants. Heparins induce a two-step conformational activation of antithrombin, a process that has remained challenging to target with molecules devoid of t