132639-29-3

Upstream product

• 102308-32-7 (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 1449-46-3 benzyltriphenylphosphonium bromide 

Downstream Products

• 132682-38-3 (Z)-(R)-N-Boc-2-amino-4-phenyl-3-butenol 
• 214556-66-8 ((1S,2R,3S)-2,3-Dihydroxy-1-hydroxymethyl-3-phenyl-propyl)-carbamic acid tert-butyl ester 
• 214556-67-9 ((1S,2S,3R)-2,3-Dihydroxy-1-hydroxymethyl-3-phenyl-propyl)-carbamic acid tert-butyl ester 
• 674777-51-6 N-[(1S,2R,3S)-2-bromo-3-hydroxy-3-phenyl-1-[(R_S)-phenylsulfinylmethyl]propyl]-4-methyl-1-benzenesulfonamide 
• 674777-52-7 N-[(1S,2R,3S)-2-bromo-3-hydroxy-3-phenyl-1-[(S_S)-phenylsulfinylmethyl]propyl]-4-methyl-1-benzenesulfonamide 
• 674777-38-9 N-[(1R,2E)-3-phenyl-1-[(R_S)-phenylsulfinylmethyl]-2-propenyl]-4-methyl-1-benzenesulfonamide 
• 674777-37-8 N-[(1R,2E)-3-phenyl-1-[(S_S)-phenylsulfinylmethyl]-2-propenyl]-4-methyl-1-benzenesulfonamide 
• 674777-31-2 [(E)-(R)-1-((R)-Benzenesulfinylmethyl)-3-phenyl-allyl]-carbamic acid tert-butyl ester 
• 674777-28-7 [(E)-(R)-1-((S)-Benzenesulfinylmethyl)-3-phenyl-allyl]-carbamic acid tert-butyl ester 
• 674777-25-4 ((E)-(R)-3-Phenyl-1-phenylsulfanylmethyl-allyl)-carbamic acid tert-butyl ester 
• 674777-21-0 (E)-2-(tert-butyloxycarbonylamino)-4-phenyl-3-butenyl methanesulfonate 
• 133625-99-7 (2R,3E)-2-(tert-butyloxycarbonylamino)-4-phenyl-3-buten-1-ol 

Relevant academic research and scientific papers

(2R,1'S,2'R,3'S)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine (PCCG-13), the first potent and selective competitive antagonist of phospholipase D- coupled metabotropic glutamate receptors: Asymmetric synthesis and preliminary biological properties

The asymmetric synthesis of(2R,1'S,2'R,3'S)-2-(2'-carboxy-3'- phenylcyclopropyl)glycine (PCCG-13), a trisubstituted carboxycyclopropylglycine endowed with unusual stereochemical features, is described. Preliminary biological evaluation demonstrates PCCG-1

Regio- and stereoselective synthesis of 1,3-aminoalcohol derivatives from allylamine derivatives via internal sulfinyl group participation

The regio- and stereoselective preparation of 1,3-aminoalcohol derivatives from protected allylamines via intramolecular participation by the sulfinyl group is reported. A carbamate protecting group on nitrogen leads to products arising from nucleophilic

Efficient access to chiral trans-2,6-dialkyl-1,2,5,6-tetrahydropyridines via allylation of chiral imines and ring-closing metathesis

Enantiomerically pure trans-2,6-dialkyl-1,2,5,6-tetrahydropyridines are synthesized in five steps from Garner's aldehyde in 37-44% overall yield. This strategy is based on the allylation of chiral iminoalcohols formed in situ followed by a ring-closing metathesis.

A short and efficient synthesis of phytosphingosines using asymmetric dihydroxylation

A short synthesis of the phytosphingosine derivatives and their stereoisomers by using asymmetric dihydroxylation of the optically active olefins derived from L-serine is described.

SYNTHESIS OF ASYMMETRIC (E)-α-GLYCINES FROM SERINE BY DIASTEREOSELECTIVE DIBROMOCYCLOPROPANATION

An asymmetric synthesis of (E)-α-2-phenylcyclopropyl)glycines and also of a homolog of allocoronamic acid, namely (E)-α-(2-ethylcyclopropyl)glycine, is reported.The key step is the dibromocyclopropanation of tert-butyl (E, 4R)- or (E, 4S)-2,2-dimethyl-4-

Synthesis of asymmetric (E)-α-(2-phenylcyclopropyl)glycines

An asymmetric synthesis of (E)-α-(2-phenylcyclopropyl)glycines is reported. The key step is the dibromocyclopropanation of tert-Butyl (E,4R) or (E,4S)-2,2-dimethyl-4-(2'-phenylvinyl)-3-oxazolidinecarboxylates, easily prepared from L or D-serine, respectiv