132640-14-3

Usage

General Description

1,3-Benzenedicarboxylic acid, 5-[(4-methylbenzoyl)amino]- is a chemical compound with a complex structure consisting of a benzene ring with two carboxylic acid groups and an attached 5-[(4-methylbenzoyl)amino] moiety. 1,3-Benzenedicarboxylic acid, 5-[(4-methylbenzoyl)amino]-, also known as 4-Methyl-N-(5-sulfoisophthaloyl)anthranilic acid, is commonly used as a dye intermediate, especially in the production of reactive dyes. It is also utilized in the manufacturing of pigments, pharmaceuticals, and other industrial products. Additionally, it can be found in some consumer products such as cosmetics and personal care items. However, due to its complex structure and potential for environmental and health hazards, proper handling and disposal procedures must be followed when working with 1,3-Benzenedicarboxylic acid, 5-[(4-methylbenzoyl)amino]-.

Upstream product

• 325981-27-9 methyl 3-(Methoxycarbonyl)-5-[(4-methylphenyl)carbonylamino]benzoate 
• 99-31-0 5-aminoisophthalic acid 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 1098411-81-4 5-[(4-Methylphenyl)carbonylamino]benzene-1,3-dicarbonyl Chloride 

Relevant academic research and scientific papers

Naphthylsulfonic acids and related compounds as glucose uptake agonists

Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or mixtures of stereoisomers, or their pharmaceutically acceptable salts, are useful in methods of stimulating the kinase activity of the insulin receptor, enhancing the activation of the insulin receptor by insulin, and stimulating the uptake of glucose into cells. A variety of antidiabetic compounds and pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.

Derivatives of N-phenylbenzamide with anti-ulcer and anti-allergy

Derivatives of N-phenylbenzamide with general formula (1) in which R1 is a cyano, nitro, halogen, hydrozy, C1 -C4 alkyl methyl, methoxy or tetrazol-5-yl group, R2 is hydrogen, hydroxy, or methoxy, R3 is a tetrazol-5-yl group or hydrogen, R4 and R5 are hydrogen if R3 is tetrazolyl but are independently selected from the group consisting of carboxy, methoxycarbonyl, ethoxycarbonyl and carbamoyl if R3 is hydrogen, and R6 is hydrogen or methyl. The derivatives have an anti-ulcer and anti-allergy activity.

Antiallergic and cytoprotective activity of new N-phenylbenzamido acid derivatives

A series of new N-phenylbenzamido acid derivatives was synthesized and evaluated for their ability to inhibit the IgE-mediated passive cutaneous anaphylaxis in the rat (PCA), as well as for their capacity to inhibit gastric mucosal damage induced by the oral administration of absolute alcohol in the rat. Some of these new derivatives exhibit potent antiallergic and cytoprotective activity, 20-80 times higher than that of the reference, disodium cromoglycate (DSCG). Structure-activity relationships are discussed. The antiallergic activity of one of the more potent compounds of this series, i.e. 4-(1H-tetrazol-5-yl)-N-[4-(1H-tetrazol-5-yl)phenyl]benzamide (compound 44, CR 2039) was further evaluated in vivo. This compound antagonizes the bronchoconstriction induced by aerosolized ovalbumin in both anesthetized and conscious IgE sensitized guinea pigs with ID50 of 3.7 mg/animal (tracheal insufflation) and 20 mg/kg (im). Further cytoprotective effects were evaluated in gastric ulcer models induced by the acute oral administration of hypertonic sodium chloride solution or by acetic acid and by the subchronic administration of glucose in fasted animals. In the models used experimentally CR 2039 is effective, whereas DSCG seems to be devoid of any protective activity. Such a potent antiallergic and mucosal protectant could provide a new potential agent in the therapy of atopic allergic diseases.