132644-87-2

Upstream product

• 501-53-1 benzyl chloroformate 
• 122603-49-0 2,2-dimethyl-4,5-endo-bis(phenylsulfonyl)-7-oxa-1-azabicyclo<2.2.1>heptane 
• 132644-75-8 2,2-dimethyl-5-(phenylsulfonyl)-4-piperidone 
• 132644-77-0 5-Benzenesulfonyl-2,2-dimethyl-4-oxo-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

SUBSTITUTED, SATURATED AND UNSATURATED N-HETEROCYCLIC CARBOXAMIDES AND RELATED COMPOUNDS FOR THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted, saturated and unsaturated N-heterocyclic carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

Tandem Addition-Cycloaddition Reaction of Oximes with 2,3-Bis(phenylsulfonyl)-1,3-butadiene as a Method for 4-Piperidone Synthesis

The reaction of oximes with 2,3-bis(phenylsulfonyl)-1,3-butadiene affords 7-oxa-1-azanorbornanes in high yield.The formation of the bicyclic isoxazolidine involves conjugate addition of the oxime onto the diene to give a transient nitrone that ten undergo