132646-01-6

Basic information

• Product Name: 2-(hydroxy(phenyl)methyl)-2-methylcyclohexanone
• Synonyms: 2-(hydroxy(phenyl)methyl)-2-methylcyclohexanone
• CAS NO: 132646-01-6
• Molecular Formula: C₁₄H₁₈O₂
• Molecular Weight: 0
• Mol File: 132646-01-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 354.8°C at 760 mmHg
• Flash Point: 151.2°C
• Appearance: /
• Density: 1.102g/cm³
• Vapor Pressure: 1.2E-05mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 2-(hydroxy(phenyl)methyl)-2-methylcyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(hydroxy(phenyl)methyl)-2-methylcyclohexanone(132646-01-6)
• EPA Substance Registry System: 2-(hydroxy(phenyl)methyl)-2-methylcyclohexanone(132646-01-6)

Safety Data

• Hazardous Substances Data: 132646-01-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 99, p. 7705, 1977 DOI: 10.1021/ja00465a049

InChI:InChI=1/C14H18O2/c1-14(10-6-5-9-12(14)15)13(16)11-7-3-2-4-8-11/h2-4,7-8,13,16H,5-6,9-10H2,1H3

Upstream product

• 127813-10-9 1-(Dimethyl-phenyl-silanyl)-2-methyl-cyclohex-2-enol 
• 1121-18-2 2-methyl-2-cyclohexen-1-one 
• 65335-75-3 [(1-methylcyclohex-1-en-2-yl)oxy]dimethylphenylsilane 
• 100-52-7 benzaldehyde 
• 65979-78-4 2-Methyl-2-phenylselanyl-cyclohexanone 
• 19980-35-9 1-trimethylsilyloxy-2-methyl-1-cyclohexene 

Relevant articles and documents

A NEW STEREOSELECTIVE ALDOL REACTION USING α-(PHENYLSELENO)CYCLOALKANONES

The TiCl4-catalyzed reaction of α-(phenylseleno)cycloalkanones with aldehydes gives aldol products with high threo selectivity.High stereoselectivity is also achieved in the formation of spiro aldol products starting with α-(phenylseleno)cycloalkanones bearing an aldehyde chain.

1,2-Addition of dimethyl(phenyl)silyllithium to cyclic α,β-unsaturated ketones and regiospecific generation of cyclic silyl enol ethers through Brook rearrangement of the 1,2-addition products

A highly convenient two-step sequence for the regiospecific synthesis of cyclic silyl enol ethers has been developed involving the 1,2-addition of dimethyl(phenyl)silyllithium to cyclic α,β-unsaturated ketones followed by the treatment of the resulting silyl carbinols with a catalytic amount of NaH in THF at 25°C.