132646-27-6

Basic information

• Product Name: 4-<2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy>benzyl alcohol
• Synonyms: 4-<2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy>benzyl alcohol
• CAS NO: 132646-27-6
• Molecular Weight: 309.365
• Mol File: 132646-27-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-<2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy>benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-<2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy>benzyl alcohol(132646-27-6)
• EPA Substance Registry System: 4-<2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy>benzyl alcohol(132646-27-6)

Safety Data

• Hazardous Substances Data: 132646-27-6(Hazardous Substances Data)

Upstream product

• 103788-65-4 (5-methyl-2-phenyloxazol-4-yl)ethanol 
• 459-57-4 4-fluorobenzaldehyde 
• 103788-59-6 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzaldehyde 

Downstream Products

• 132646-28-7 4-[2-(4-Chloromethyl-phenoxy)-ethyl]-5-methyl-2-phenyl-oxazole 
• 103788-59-6 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzaldehyde 
• 201660-20-0 4-[2-(4-bromomethyl-phenoxy)-ethyl]-5-methyl-2-phenyl-oxazole 
• 132646-29-8 N-(triphenylmethyl)-5-<4-<2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy>benzyl>-2,4-oxazolidinedione 
• 132646-30-1 5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl}-2,4-oxazolidinedione 
• 166253-18-5 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenylacetonitrile 
• 250601-46-8 methyl (E)-4-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyloxyimino}-4-phenylbutyrate 

Relevant articles and documents

ORGANIC COMPOUNDS

Compounds of the formula (I) provide pharmacological agents which bind to Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the present invention are useful for the treatment of conditions mediated by the PPAR receptor activity in mammals. Such conditions include dyslipidemia, hyperlipidemia, hypercholesteremia, atherosclerosis, hypertriglyceridemia, heart failure, myocardial infarction, vascular diseases, cardiovascular diseases, hypertension, obesity, inflammation, arthritis, cancer, Alzheimer's disease, skin disorders, respiratory diseases, ophthalmic disorders, inflammatory bowel diseases (IBDs), ulcerative colitis and Crohn's disease. The compounds of the present invention are particularly useful in mammals as hypoglycemic agents for the treatment and prevention of conditions in which impaired glucose tolerance, hyperglycemia and insulin resistance are implicated, such as type-1 and type-2 diabetes, and Syndrome X.

Novel 5-substituted-1H-tetrazole derivatives as potent glucose and lipid lowering agents.

A series of 5-(4-alkoxyphenylalkyl)-1H-tetrazole derivatives, containing an oxazole-based group at the alkoxy moiety, was prepared and their antidiabetic effects were evaluated in two genetically obese and diabetic animal models, KKAy mice and Wistar fatt