132646-41-4Relevant academic research and scientific papers
Benzyloxazolidine-2,4-diones as potent hypoglycemic agents
Dow,Bechle,Chou,Clark,Hulin,Stevenson
, p. 1538 - 1544 (2007/10/02)
A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.
