132649-24-2

Upstream product

• 100-51-6 benzyl alcohol 
• 122-52-1 triethyl phosphite 

Downstream Products

• 76385-23-4 [2-(Ethoxycarbonyl-ethyl-amino)-ethyl]-phosphonic acid diethyl ester 
• 76385-32-5 [2-(Benzyl-ethoxycarbonyl-amino)-ethyl]-phosphonic acid diethyl ester 
• 76385-31-4 [2-(Ethoxycarbonyl-ethyl-amino)-ethyl]-phosphonic acid benzyl ester ethyl ester 
• 76385-33-6 [2-(Benzyl-ethoxycarbonyl-amino)-ethyl]-phosphonic acid benzyl ester ethyl ester 

Relevant academic research and scientific papers

Alcohol-based Michaelis-Arbuzov reaction: An efficient and environmentally-benign method for C-P(O) bond formation

The famous Michaelis-Arbuzov reaction is extensively used both in the laboratory and industry to manufacture tons of widely-used organophosphoryl compounds every year. However, this method and the modified Michaelis-Arbuzov reactions developed recently still have some limitations. We now report a new alcohol-version of the Michaelis-Arbuzov reaction that can provide an efficient and environmentally-benign method to address the problems of the known Michaelis-Arbuzov reactions. That is, a wide range of alcohols can readily react with phosphites, phosphonites, and phosphinites to give all the three kinds of phosphoryl compounds (phosphonates, phosphinates, and phosphine oxides) using an n-Bu4NI-catalyzed efficient C-P(O) bond formation reaction. This general method can also be easily scaled up and used for further synthetic transformations in one pot.