1326643-05-3Relevant academic research and scientific papers
High-affinity DNA targeting using readily accessible mimics of N2′-functionalized 2′-amino-α-L-LNA
Karmakar, Saswata,Anderson, Brooke A.,Rathje, Rie L.,Andersen, Sanne,Jensen, Troels B.,Nielsen, Poul,Hrdlicka, Patrick J.
, p. 7119 - 7131 (2011/10/31)
N2′-Pyrene-functionalized 2′-amino-α-L-LNAs (locked nucleic acids) display extraordinary affinity toward complementary DNA targets due to favorable preorganization of the pyrene moieties for hybridization- induced intercalation. Unfortunately, the synthes
